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TranscriptomicsBrain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor’s barrier avoidance, startled jumping, and retarded locomotion. Transcripts in...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-45035 | biostudies-arrayexpress
TranscriptomicsA comprehensive analysis of blood host responses to Yersinia Pestis infection Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis
transcriptomic analyses showed there was a very rapid proliferation of Y. pestis in assault on African green monkeys. The bacterial loads were enumerated in the blood at delayed time points supporting earlier observations (Layton et al., 2011). Interpretation of transcriptomic changes reveals that...
ORGANISM(S): Chlorocebus aethiops 
2016-01-14 | E-GEOD-63560 | biostudies-arrayexpress
TranscriptomicsDermal Wound Transcriptomic Responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae
Bacterial infections of wounds are associated with poor healing and worse scarring. We sought to identify transcriptomic patterns associated with impaired healing of wounds infected with Klebsiella pneumoniae (K.p.) or Pseudomonas aeruginosa (P.a.) using a rabbit ear wound model. Wounds created on p...
ORGANISM(S): Oryctolagus cuniculus 
2014-01-01 | E-GEOD-51167 | biostudies-arrayexpress
TranscriptomicsImmune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably, extraterrestrial infection ma...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54213 | biostudies-arrayexpress
TranscriptomicsRole of omega-3 fatty acids regulating the brain functions and associated disorders: Transcriptomic analysis of the effect of a fish oil enriched diet on murine brains
Based on the comprehensive inhibition of a pool of inflamamsome and apoptosome networks, FD likely reduces the amyloidal burden, attenuates oxidative stress and assist somatostatin activation. Thus FD is a potential therapeutic agent for Alzheimer’s disease, Parkinson’s disease and affective disorde...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-46933 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study2]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our time-course study (Study II) with three experimental conditions where we varied the length of time that subservient mice were exposed t...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52871 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggr...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52866 | biostudies-arrayexpress
TranscriptomicsmiRNA expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggr...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52869 | biostudies-arrayexpress
TranscriptomicsmiRNA expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study2]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our time-course study (Study II) with three experimental conditions where we varied the length of time that subservient mice were exposed t...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52872 | biostudies-arrayexpress
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