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MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
UnknownHypoxia-inducible factor expression is related to apoptosis and cartilage degradation in temporomandibular joint osteoarthritis.
Not available
S-EPMC9202126 | biostudies-literature
UnknownEfficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.
Not available
S-EPMC5131925 | biostudies-literature
ProteomicsProfiling of mouse sciatic nerve acetylome
Lysine acetylation is a reversible Post-translational modification (PTM) involved in a broad array of physiological functions. Recent studies have demonstrated the involvement of protein acetylation in modulating Schwann cells' (SCs) biology and the peripheral nervous system (PNS) regeneration. Howe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD029611 | Pride
Acetylome Sciatic nerve Mouse Acetylation Schwann cells 
ProteomicsPDI-catalyzed oxidative protein folding mediates senescence by induction of ER-derived oxidative stress
Protein homeostasis is linked with aging and aging associated diseases. Oxidative protein folding occurs in the endoplasmic reticulum (ER) and produces H2O2 as a byproduct. The role of oxidative protein folding in human stem cells aging remains unknown. Here, we succeed to knockout protein disulfide...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD037244 | Pride
Human mesenchymal stem cells (hmscs)  hydrogen peroxide (h2o2)  oxidative 29 protein folding  protein disulfide isomerase (pdi)  senescence 
UnknownWill Sofosbuvir/Ledipasvir (Harvoni) Be Cost-Effective and Affordable for Chinese Patients Infected with Hepatitis C Virus? An Economic Analysis Using Real-World Data.
Not available
S-EPMC4898683 | biostudies-literature
UnknownIGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis.
Not available
S-EPMC11659520 | biostudies-literature
ProteomicsRat sensory and motor nerve fibroblasts LC-MSMS
In this study, a quantitative proteomic technique based on isobaric tags for relative and absolute quantitation (iTRAQ) was used to compare the proteome of cultured sensory and motor nerve fibroblasts (Fbs). Among a total of 2597 overlapping proteins identified, we obtained 148 differentially expres...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD034827 | Pride
Lc-msms Sensory nerve fibroblasts Motor nerve fibroblasts Rat 
MetabolomicsMetabolomic Analysis Reveals an Important Role of Sphingosine 1-phosphate in the Development of HFMD due to EV-A71 Infection

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovi...

2024-11-14 | MTBLS11656 | MetaboLights
UnknownCounterintuitive solvation effect of ionic-liquid/DMSO solvents on acidic C-H dissociation and insight into respective solvation.
Not available
S-EPMC8152793 | biostudies-literature
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