Sort   by:  
 Page size 
MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
GenomicsAntirrhinum majus x Antirrhinum molle
Antirrhinum majus x Antirrhinum molle Map
PRJNA72329 | ENA
ProteomicsCRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice
Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X syndrome (FXS), an inherited neurodevelopmental disorder resulting in intellectual disability and autism-spectrum disorder. Despite the prevalence of the FXS, the molecular function of FMRP remains uncertain. Here, we showed that...
ORGANISM(S): Homo sapiens (Human) 
2026-04-20 | PXD067852 | Pride
Hek293t 
UnknownActivation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury.
Not available
S-EPMC4527689 | biostudies-literature
TranscriptomicsDynamics of gene silencing during X inactivation using allele-specific RNA-Seq
Background: During early embryonic development, one of the two X chromosomes in mammalian female cells is inactivated to compensate for a potential imbalance in transcript levels with male cells containing a single X chromosome. We use mouse female Embryonic Stem Cells (ESCs) with nonrandom XCI and ...
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-60738 | biostudies-arrayexpress
UnknownEvaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
Not available
S-EPMC2367546 | biostudies-literature
UnknownA route to phase controllable Cu2ZnSn(S(1-x)Se(x))4 nanocrystals with tunable energy bands.
Not available
S-EPMC3781399 | biostudies-literature
GenomicsExome Sequencing for Diseases of the Immune System: X-linked Immunodeficiency with Magnesium Defect, EBV Infection, and Neoplasia (XMEN)

The etiologies of primary immunodeficiencies often yield novel insights about the immune system. Although a genetic etiology has been suspected for patients with abnormally low CD4+ T cells in the absence of HIV infection or any known causes of lymphopenia, no genetic mutation has been de...

phs000365.v1.p1 | EGA
TranscriptomicsTranscriptional regulation in pluripotent stem cells by Methyl CpG binding protein 2 (MeCP2)
Rett syndrome (RTT) is one of the most prevalent female mental disorders. De novo mutations in methyl CpG binding protein 2 (MeCP2) are a major cause of RTT. MeCP2 regulates gene expression as a transcription regulator as well as through long-range chromatin interaction. Because MeCP2 is present on ...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51607 | biostudies-arrayexpress
Sort   by:  
 Page size