Sort   by:  
 Page size 
TranscriptomicsSequential stage specific reporter line analysis (SSRLA) of 3 BAC transgenic mESC lines
FACS purified cells from differentiation day 14-15 cells from 3 BAC transgenic mESC lines: Hes::GFP (early), Nurr1::GFP (mid), and Pitx3::YFP (late) DA neuron development reporter lines All three lines were differentiated towards the midbrain dopamine phenotype, and FACS purification was performed ...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37446 | biostudies-arrayexpress
TranscriptomicsRemission in Juvenile Idiopathic Arthritis Achieved on Different Drug Regimens
Remission has become both the gold standard for clinical care and the end point for clinical trials for children with juvenile idiopathic arthritis (JIA). Using gene expression microarrays, we found that when remission induced by methotrexate (MTX) or MTX plus a TNF inhibitor (etanercept, Et) (MTX+E...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-41831 | biostudies-arrayexpress
MetabolomicsPlasma metabolite changes in dairy cows during parturition identified using untargeted metabolomics
The metabolic responses of cows undergo substantial changes during the transition from late pregnancy to early lactation. However, the molecular mechanisms associated with these changes in physiological metabolism have not been clearly elucidated. The objective of this study was to investigate metab...
2019-08-20 | MTBLS809 | MetaboLights
MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
ProteomicsHepatocellular carcinoma cell lines LC-MS/MS
Hepatocellular carcinoma (HCC) ranks sixth among the most common malignancies and fourth in mortality among all kinds of cancers in the world. Recent advances in early diagnosis and therapeutics have led to improved survival of HCC patients, but the recurrence and metastasis are still main reasons f...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017033 | Pride
Intact glycopeptide Emt Site-specific glycosylation Mass spectrometry Hepatocellular carcinoma Glycoproteome 
ProteomicsProximity labeling proteins differences between TRIM25 and G3BP1 interactions or not, and Proximity labeling proteins differences between G3BP1 and TRIM25 in the presence or absence of poly(I:C) stimulation
This project investigates G3BP1 proximity proteins by constructing a G3BP1-BirA* fusion protein using G3BP1 as a decoy protein and BirA* as a biotin ligase. The changes in G3BP1 proximity proteins were studied in the presence or absence of poly(I:C) stimulation conditions, using poly(I:C) stimulatio...
ORGANISM(S): Homo Sapiens 
2023-07-07 | PXD043603 |
MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
MetabolomicsMetabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites
The objective of the study was to identify the fertility-associated metabolites in bovine spermatozoa using liquid chromatography-mass spectrometry (LC-MS). Six Holstein Friesian crossbred bulls (three high-fertile and three low-fertile bulls) were the experimental animals. Sperm proteins were isola...
2021-12-07 | MTBLS1071 | MetaboLights
MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
ProteomicsS6K1 Phosphoproteome in Tsc1-null mouse kidney iMCD3 cells
Loss of Tsc1 in the kidneys gives rise to rapid polycystogenesis and kidney failure due to the hyperactivation of mTOR complex I (mTORC1). One of the major downstream targets of mTORC1 is S6K1, which is responsible for driving many of the effector functions of mTOR. Strikingly, the loss of S6k1 in t...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD014832 | Pride
S6k1 Tsc1 Kidney Phosphoproteome Mtor 
Sort   by:  
 Page size