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TranscriptomicsRevealing different roles of the mTOR-targets S6K1 and S6K2 in breast cancer by expression profiling and structural analysis
Expression profiles of ZR751 breast cancer cells after downregulation of S6K1, S6K2 and S6K1+S6K2. Triplicates of control, S6K1siRNA, S6K2siRNA and S6K1+S6K2siRNA, in total twelve samples.
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-75813 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse long-lived S6K1 -/- strain females compared to wild types
We examined the transcript changes in long-lived S6K1-/- female mice compared to wild type controls.
ORGANISM(S): Mus musculus 
2009-09-04 | E-MEXP-2320 | biostudies-arrayexpress
ProteomicsS6K1 Phosphoproteome in Tsc1-null mouse kidney iMCD3 cells
Loss of Tsc1 in the kidneys gives rise to rapid polycystogenesis and kidney failure due to the hyperactivation of mTOR complex I (mTORC1). One of the major downstream targets of mTORC1 is S6K1, which is responsible for driving many of the effector functions of mTOR. Strikingly, the loss of S6k1 in t...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD014832 | Pride
S6k1 Tsc1 Kidney Phosphoproteome Mtor 
ProteomicsS6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal ...
ORGANISM(S): Homo Sapiens 
2021-08-27 | PXD028167 |
GenomicsGenomewide analysis of S6K1-depleted human dorsal forebrain organoids [ATAC-seq]
Genomewide analysis of S6K1-depleted human dorsal forebrain organoids [ATAC-seq]
PRJNA885026 | ENA
GenomicsGenomewide analysis of S6K1-depleted human dorsal forebrain organoids [RNA-seq]
Genomewide analysis of S6K1-depleted human dorsal forebrain organoids [RNA-seq]
PRJNA885025 | ENA
GenomicsS6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 proten stability
Study of S6K1 and S6K2 functions in HR DNA repair
PRJEB115785 | ENA
GenomicsS6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 proten stability
Study of S6K1 and S6K2 functions in HR DNA repair
PRJEB115736 | ENA
GenomicsGenomewide analysis of S6K1-depleted human dorsal forebrain organoids [single-cell RNA-seq]
Genomewide analysis of S6K1-depleted human dorsal forebrain organoids [single-cell RNA-seq]
PRJNA972001 | ENA
GenomicsTargeting S6K1 and S6K2 by siRNA and sgRNA in LN229 GBM cells
Targeting S6K1 and S6K2 by siRNA and sgRNA in LN229 GBM cells
PRJNA805545 | ENA
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