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TranscriptomicsExpression Signatures in Polyarticular JIA Show Heterogeneity and Offer a Molecular Classification of Disease Subsets
Objective. Microarray analysis was used to determine whether children with recent onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures in peripheral blood mononuclear cells (PBMC). Methods. Peripheral blood samples were o...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-13849 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of cells derived from the site of inflammation of Juvenile Idiopathic Arthritis patients
Through RNA sequencing of CD4+ Tmemory/effector cells derived from the synovium of JIA patients and healthy controls, we analyzed the JIA gene expression signature. Treatment of autoinflammatory site-derived patient T cells with the BET-inhibitor JQ1 inhibited immune-related super-enhancers and pref...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-71595 | biostudies-arrayexpress
GenomicsEpigenetic profiling of Juvenile Idiopathic Arthritits (JIA) patients
With H3K27ac chromatin immunoprecipitation we identified a disease-specific, inflammation-associated, (super-)enhancer signature in JIA patient synovial fluid-derived CD4+ memory/effector T cells. This signature consists of unique pathogenesis-associated epigenetic changes which extend beyond genera...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-71596 | biostudies-arrayexpress
TranscriptomicsSubtype-specific peripheral blood gene expression profiles in recent onset JIA
Objective: A multi-center study of recent onset juvenile idiopathic arthritis (JIA) subjects prior to treatment with DMARDS or biologics was undertaken to identify peripheral blood gene expression differences between JIA subclasses and controls. Methods: PBMC from 59 healthy children and 136 JIA ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-13501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood samples from juvenile idiopathic arthritis (JIA) patients pre and post methotrexate therapy. Expression data from SPARKS CHARMS JIA cohort
Gene expression on peripheral blood mononuclear cells (PBMC) from SPARKS CHARMS juvenile idiopathic arthritis (JIA) cohort pre and post methotrexate therapy. This is the first study to our knowledge, to evaluate gene expression profiles in children with JIA before and after MTX, and to analyze genet...
ORGANISM(S): Homo sapiens 
2010-09-27 | E-GEOD-23687 | biostudies-arrayexpress
ProteomicsIdentification of the interactors of Jlp2 in S. cerevisiae
A label-free quantitative pull-down experiment was performed to identify the interactors of Jlp2 in S. cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-09-17 | PXD067959 | Pride
Ap-ms S. cerevisiae Jlp2 
TranscriptomicsJuvenile idiopathic arthritis: peripheral blood cells
Systemic-onset juvenile idiopathic arthritis (soJIA) is a rheumatic disease in childhood characterized by systemic symptoms and a relatively poor prognosis. The peripheral leukocytes are thought to play the pathological role of soJIA although the exact cause is still obscure. In this study, we aimed...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8361 | biostudies-arrayexpress
ProteomicsFAT-switch-based quantitative S-nitrosoproteomics reveals a key role of GSNOR1 in regulating ER functions
Reversible protein S-nitrosylation regulates a wide range of biological functions and physiological activities in plants. However, it is challenging to quantitively determine the S-nitrosylation targets and dynamics in vivo. In this study, we developed a highly sensitive and efficient fluorous affin...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-06-07 | PXD037504 | Pride
S-nitrosylation  fluorous affinity tags  er stress  transcription  proteomics  redox homeostasis 
UnknownThe successes and challenges of harmonising juvenile idiopathic arthritis (JIA) datasets to create a large-scale JIA data resource.
Not available
S-EPMC10339614 | biostudies-literature
ProteomicsProtein S-Nitrosylation of host and viral proteins upon fibroblast infection with Human Cytomegalovirus
Human Cytomegalovirus (HCMV) is a ubiquitous pathogen that has co-evolved with its host and in doing so, is highly efficient in undermining antiviral responses that limit successful infections. As a result, HCMV infections are highly problematic in individuals with weakened or underdeveloped immune ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD019208 | Pride
Hcmv Protein s-nitrosylation Cytomegalovirus 
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