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UnknownDisGeNet: a disease-centric interaction database among diseases and various associated genes.
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S-EPMC11724190 | biostudies-literature
ProteomicspSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate
In this study, we used a novel strategy of pSILAC method coupled with two complementary digestion approaches to find potential substrates of E7070, and reveals PRPF39 as E7070-dependent DCAF15 substrate.
ORGANISM(S): Homo Sapiens 
2019-10-18 | PXD015892 |
ProteomicsMulti-Omics Analysis Reveals RNA Polymerase II Degradation as a Novel Mechanism of PF-3758309's Anti-Tumor Activity
In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) vi...
ORGANISM(S): Homo Sapiens 
2025-06-05 | PXD064705 |
ProteomicsSpatiotemporally direct capturing global substrates of post-translational modifying enzymes in living cells
Methods for direct capturing global substrates of protein-modifying enzymes in living cells are with many challenges, and yet largely unexplored. Here, we report a strategy to directly capture substrates of protein-modifying enzymes via PTM-acceptor residue crosslinking in living cells, enabling glo...
ORGANISM(S): Escherichia Coli 
2023-02-22 | PXD040318 |
ProteomicsGlobal identification ofphospho-dependent SCF ubiquitin ligase substrate reveal a role of ERK-FBXO22-BAG3 axis in tumorigenesis
293T cells were cultured in SILAC medium. Heavy group was labeled with K6&R10. Light group was labeled with K0&R0. In light group, cells were treated with MLN4924. In heavy group, cells were treated with DMSO. Then cells were lysed, mixed and tryptic digested. Peptide mixture was subjected to phosph...
ORGANISM(S): Homo Sapiens 
2021-06-29 | PXD027020 |
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