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UnknownBlood Cathepsins on the Risk of Alzheimer's Disease and Related Pathological Biomarkers: Results from Observational Cohort and Mendelian Randomization Study.

Background

Alzheimer's disease (AD), the main type of dementia, involves in complex pathophysiological processes, including abnormal lysosomes function. Cathepsins are the predominant proteases responsible for the degradation of diverse substrates in the endo-lysosomal system. However, there...
S-EPMC11573867 | biostudies-literature
UnknownRegorafenib inhibited gastric cancer cells growth and invasion via CXCR4 activated Wnt pathway.

Aim

Regorafenib is an oral small-molecule multi kinase inhibitor. Recently, several clinical trials have revealed that regorafenib has an anti-tumor activity in gastric cancer. However, only part of patients benefit from regorafenib, and the mechanisms of regorafenib's anti-tumor effect need...
S-EPMC5425213 | biostudies-literature
ProteomicsHuman BRS3 receptor activation LC-MSMS
Bombesin-like receptor 3 (BRS3), an orphan G protein–coupled receptor (GPCR), plays important roles in our biological system while the exact mechanisms behind are less known. To get insights of biological effects on BRS3 activation, we utilized quantitative proteomics approach to explore the dynamic...
ORGANISM(S): Homo sapiens (Human) 
2020-02-25 | PXD017104 | Pride
Human brs3 lc-msms 
ProteomicsProteomics analysis of cellular nucleic acid binding proteins
Organic solvents and Ti4+-IMAC capture of formaldehyde (FA) cross-linked cells followed by mass spectrometry analysis to identify nucleic acid binding proteins in human cells.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD026035 | Pride
Nucleic acid binding protemoics Lc/ms-ms Human lung cancer 
UnknownIdentification of a novel m6A-related lncRNAs signature and immunotherapeutic drug sensitivity in pancreatic adenocarcinoma.

Background

Pancreatic adenocarcinoma (PDAC) ranks as the fourth leading cause for cancer-related deaths worldwide. N6-methyladenosine (m6A) and long non-coding RNAs (lncRNAs) are closely related with poor prognosis and immunotherapeutic effect in PDAC. The aim of this study is to construct a...
S-EPMC10804632 | biostudies-literature
UnknownVitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.

Background

Vitamin K-dependent γ-glutamic acid carboxylation (Gla) proteins are calcium-binding and membrane-associated, participating in coagulation, bone turnover, and cancer biology. The molecular function of transmembrane proline-rich Gla proteins (PRRGs) remains unexplored.

Methods

S-EPMC11753899 | biostudies-literature
UnknownUBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer.

Background

Ubinuclein-2 (UBN2) is a nuclear protein that interacts with many transcription factors. The molecular role and mechanism of UBN2 in the development and progression of cancers, including colorectal cancer (CRC), is not well understood. The current study explored the role of UBN2 i...
S-EPMC6511126 | biostudies-literature
UnknownDiagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study.

Objective

To evaluate the diagnostic accuracy and safety of using magnetically guided capsule endoscopy with a detachable string (ds-MCE) for detecting and grading oesophagogastric varices in adults with cirrhosis.

Design

Prospective multicentre diagnostic accuracy study.

Setting

S-EPMC10912951 | biostudies-literature
UnknownAggressive NK-cell leukemia: clinical subtypes, molecular features, and treatment outcomes.
Not available
S-EPMC5802497 | biostudies-literature
UnknownCharacteristics of home oxygen therapy for preterm infants with bronchopulmonary dysplasia in China: results of a multicenter cohort study.

Background

Home oxygen therapy (HOT) is indicated upon discharge in some preterm infants with severe bronchopulmonary dysplasia (BPD). There is a lack of evidence-based consensus on the indication for HOT among these infants. Because wide variation in the institutional use of HOT exists, lit...
S-EPMC10198895 | biostudies-literature
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