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UnknownMechanical power is not associated with mortality in COVID-19 mechanically ventilated patients.

Background

The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortalit...
S-EPMC11861844 | biostudies-literature
UnknownIdentification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study.
Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at cytosine-phosphate-guanine (CpG) site level and genomic regions. A discovery cr...
S-EPMC4844221 | biostudies-literature
UnknownA common 56-kilobase deletion in a primate-specific segmental duplication creates a novel butyrophilin-like protein.

Background

The Butyrophilin-like (BTNL) proteins are likely to play an important role in inflammation and immune response. Like the B7 protein family, many human and murine BTNL members have been shown to control T lymphocytes response, and polymorphisms in human BTNL2 have been linked to se...
S-EPMC3729544 | biostudies-literature
UnknownRecommendations from the international stroke genetics consortium, part 1: standardized phenotypic data collection.
Not available
S-EPMC4465378 | biostudies-literature
UnknownCriterion-related validity and reliability of the standing long jump test in adults: The Adult-Fit project.
The purpose of this study was to analyze the criterion-related validity and the reliability of the standing long jump test (SLJ) for evaluating the lower-body explosive muscular strength in adults. A total of 410 adults participated in this study. Sociodemographic, anthropometric measurements, labor...
S-EPMC11369318 | biostudies-literature
UnknownGenetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.
Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlob...
S-EPMC9223468 | biostudies-literature
UnknownEpigenome-wide association study identifies novel genes associated with ischemic stroke.

Background

DNA methylation has previously been associated with ischemic stroke, but the specific genes and their functional roles in ischemic stroke remain to be determined. Here we aimed to identify differentially methylated genes that play a functional role in ischemic stroke in a Chinese ...
S-EPMC10304605 | biostudies-literature
UnknownThe influence of emotional burnout and resilience on the psychological distress of nursing students during the COVID-19 pandemic.
The aim of this study was to measure and analyse the association of emotional burnout and resilience with the psychological distress of students who finished their nursing studies after the peak of the COVID-19 pandemic. The mental health of nursing students was affected during the pandemic, and res...
S-EPMC9538541 | biostudies-literature
UnknownSubtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 Controls.

Background

Genome-wide association studies have identified multiple loci associated with stroke. However, the specific stroke subtypes affected, and whether loci influence both ischemic and hemorrhagic stroke, remains unknown. For loci associated with stroke, we aimed to infer the combinatio...
S-EPMC7477820 | biostudies-literature
UnknownRational Design of Metal-Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy.
Despite improvements in cancer survival rates, metastatic and surgery-resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses and limited treatment options. Enhancing drug bioavailability in tumors, while minimizing off-target effects, is crucial. Metal-organic framewor...
S-EPMC12747470 | biostudies-literature
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