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MetabolomicsDisorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis co-morbid type 2 diabetes mellitus

BACKGROUND: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms ...

2023-12-15 | MTBLS8729 | MetaboLights
UnknownSubtle mutations in the SMN1 gene in Chinese patients with SMA: p.Arg288Met mutation causing SMN1 transcript exclusion of exon7.

Background

Proximal spinal muscular atrophy (SMA) is a common neuromuscular disorder resulting in death during childhood. Around 81~95% of SMA cases are a result of homozygous deletions of survival motor neuron gene 1 (SMN1) gene or gene conversions from SMN1 to SMN2. Less than 5% of cases s...
S-EPMC3523059 | biostudies-literature
UnknownSemiconducting SN2 monolayer with three-dimensional auxetic properties: a global minimum with tetracoordinated sulfurs.
Designing new two-dimensional (2D) materials, exploring their unique properties and diverse potential applications are of paramount importance to condensed matter physics and materials science. In this work, we predicted a novel 2D SN2 monolayer (S-SN2) by means of density func...
S-EPMC7423189 | biostudies-literature
ProteomicsSexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage
Male and female collagen-enriched fraction of cartilage from bovine knees. Full thickness cartilage plugs without subchondral bone were digested with chondroitinase for 24 hours to remove proteoglycans. Cartilage was further decellularized with SDS. LUM1_811145: channels 126, 127, 128 female, chan...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
MSV000092997 | MassIVE
MetabolomicsIntegration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in pulmonary tuberculosis and pulmonary tuberculosis-complicated diabetes

Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that threaten human health. Patients with DM are susceptible to PTB, an important factor that aggravates the complications of diabetes. However, the molecular regulatory mechanism underlying the susceptibility of ...

2023-07-26 | MTBLS7623 | MetaboLights
MetabolomicsLipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis
Psoriasis is a common and chronic inflammatory skin disease complicated by genetic-environmental interactions. Although genomic, transcriptomic and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remai...
2017-08-22 | MTBLS408 | MetaboLights
ProteomicsSnake (Elaphe taeniura) IgY was truncated at N338 of the IgY heavy chain constant region
One of our previous studies has shown that there are two IgY subclasses (termed IgY1 and IgY2) in the serum of snake Elaphe taeniura, and both subclasses are expressed as full-length and shortened isoforms (IgY1-L, IgY2-L,IgY1-S, and IgY2-S). Using 2-DE and LC-MS/MS, we detected IgY1-L, IgY2-L,IgY1-...
ORGANISM(S): Elaphe Taeniura 
PXD055127 |
UnknownSingle cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody.
Not available
S-EPMC7686823 | biostudies-literature
UnknownAmplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer.
A causal role of gene amplification in tumorigenesis is well known, whereas amplification of DNA regulatory elements as an oncogenic driver remains unclear. In this study, we integrated next-generation sequencing approaches to map distant estrogen response elements (DEREs) that remotely control the ...
S-EPMC3890247 | biostudies-literature
UnknownA Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.

Background

No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.

Methods

We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory i...
S-EPMC7121492 | biostudies-literature
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