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TranscriptomicsMiR-34b regulates multiciliogenesis during organ formation in zebrafish
Multiciliated cells possess multiple motile cilia on the cell surface and are widely distributed throughout the vertebrate body to perform important physiological functions by regulating fluid movement in the intercellular space. However the molecular mechanisms underlying multiciliogenesis are not ...
ORGANISM(S): Danio rerio 
2013-06-14 | E-MEXP-3893 | biostudies-arrayexpress
Proteomicsmass spectrometry analysis of in vitro kinase assay for DNA-PKcs and TAF7
To examine whether TAF7 could be phosphorylated by DNA-PKcs directly. An in vitro kinase assays were performed. Firstly, human DNA-PKcs was purified from TGF1 treated HK2 cells by immunoprecipitation with a DNA-PKcs antibody (abcam) and IgG was used as a negative control. The purified proteins and ...
ORGANISM(S): Homo Sapiens 
2022-09-22 | PXD036930 |
TranscriptomicsDNA hypermethylation in placental tissues: placental tissues vs. maternal peripheral bloods
Noninvasive prenatal diagnosis currently used does not achieve desirable levels of sensitivity and specificity. Recently, fetal methylated DNA biomarkers in maternal whole blood have been explored for noninvasive prenatal detection. However, such efforts cover only chromosomal aneuploidy; fetal meth...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-35997 | biostudies-arrayexpress
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
ProteomicsDNA-PK drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming
Phosphoproteomics profiling of WT and DNA-PKcs-/- mouse kidney tissues was performed to reveal possible substrates of DNA-PK
ORGANISM(S): Mus Musculus 
2022-01-06 | PXD030789 |
ProteomicsIntegrative proteomic characterization of human lung adenocarcinoma
Genomic studies of lung adenocarcinoma (LUAD) have advanced understanding of the disease’s biology and accelerated targeted therapy. However, proteomic characteristics of LUAD remain poorly understood. We carried out comprehensive proteomic analysis of 103 cases of LUAD in Chinese patients. Integrat...
ORGANISM(S): Homo Sapiens 
PXD020252 |
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