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HGF has been reported to have both positive and negative effects on carcinogenesis. Here we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treate...
ORGANISM(S): Mus musculus 
Appropriate neural initiation of the pluripotent stem cells in the early embryos is critical for the development of the central nervous system. This process is regulated by the coordination of extrinsic signals and intrinsic programs. However, how the coordination is achieved to ensure proper neural...
ORGANISM(S): Mus musculus 
In this study, phosphorylation levels of Neospora caninum parasite (Nc1 strains) tachyzoites were compared with PKG inhibitor MBP146-78 treated and untreated, contains two replicates. Therefore, four subprojects are included in this project. Subproject IPX0011618001 is composed of the sub-dataset ge...
ORGANISM(S): Neospora Caninum 
2025-04-09 | PXD062765 |
Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). However, the signaling pathways regulating apoptosis in glucocorticoid-treated lymphoid cells remain unclear. In this study, pediatric ALL patient-derived xenograft inherentl...
ORGANISM(S): Homo sapiens 
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