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TranscriptomicsGenome-wide identification of rat long non-coding RNAs
In the current study, we have focused on a distinct group of non-coding elements, lncRNA, and profiled renal tissues from three different inbred rat strains. We chose the three strains S, SHR and R for the main purpose of cataloging lncRNA annotations from the most widely used rat models of cardiov...
ORGANISM(S): Rattus norvegicus 
2014-12-10 | E-GEOD-58701 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of rat long non-coding RNAs (microarray)
In the current study, we have focused on a distinct group of non-coding elements, lncRNA, and profiled renal tissues from three different inbred rat strains. We chose the three strains S, SHR and R for the main purpose of cataloging lncRNA annotations from the most widely used rat models of cardiov...
ORGANISM(S): Rattus norvegicus 
2014-12-10 | E-GEOD-59165 | biostudies-arrayexpress
TranscriptomicsDEFINING A RAT BLOOD PRESSURE QUANTITATIVE TRAIT LOCUS TO A <81.8KB CONGENIC SEGMENT: COMPREHENSIVE SEQUENCING AND RENAL TRANSCRIPTOME ANALYSIS.
Evidence from multiple linkage and genome-wide association studies suggest that human chromosome 2 (HSA2) contains alleles that influence blood pressure (BP). Homologous to a large segment of HSA2 is rat chromosome 9 (RNO9), to which a BP quantitative trait locus (QTL) was previously mapped. The obj...
ORGANISM(S): Rattus norvegicus 
2010-07-15 | E-GEOD-22515 | biostudies-arrayexpress
TranscriptomicsImpaired endosomal recycling in proximal tubules is mechanistically linked to proteinuria
Through substitution mapping studies, we previously identified that a <330kb region from a rat strain with no renal pathology (the Lewis rat), which when introgressed onto the genetic background of a rat with renal disease (the Dahl Salt-sensitive (S) rat), caused an increase rather than the expecte...
ORGANISM(S): Rattus norvegicus 
2011-12-17 | E-GEOD-30770 | biostudies-arrayexpress
TranscriptomicsEvaluation of expression quantitative trait loci within two interacting blood pressure quantitative trait loci
Genetic dissection of the S rat genome has provided strong evidence for the presence of two interacting blood pressure (BP) quantitative trait loci (QTLs), termed QTL1 and QTL2, on rat chromosome 5. However, the identities of the underlying interacting genetic factors remain unknown. Further experim...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-7628 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling with a Blood Pressure QTL interval-specific oligonucleotide array
Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identif...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-1622 | biostudies-arrayexpress
TranscriptomicsAzoxymethane-induced colorectal tumorigenesis in hypertensive rat models
To compare the tumor susceptibility between the hypertensive Dahl salt-sensitive rats (S) rat and S.LEW(10)x12x2x3x5 (S.LEW) congenic strain, one of the S.LEW congenic strains our laboratory previously constructed on rat chromosome 10 [Hypertension. 2007 Nov;50(5):891-8], Azoxymethane (AOM)-induced ...
ORGANISM(S): Rattus norvegicus 
2016-04-04 | E-GEOD-75280 | biostudies-arrayexpress
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