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ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Memory in Alzheimer's Disease Mice
Here, we present findings from a drug discovery program aimed at developing small molecules that enhance brain sCLU levels and assessed their impact on AD pathology and cognition. A high-throughput screening campaign identified two classes of epigenetic modulators to increase sCLU levels, and medici...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060171 | Pride
Alzheimers disease Epigenetic modulator Memory improvement Secreted clustering enhancer 
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
UnknownGRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model.
Not available
S-EPMC10226256 | biostudies-literature
ProteomicsDiscovery of an ApoE4-Targeted Small-Molecule SirT1 Enhancer for the Treatment of Alzheimer’s Disease
Herein we describe the discovery of an orally brain-22 permeable small-molecule, DDL-218, that enhanced SirT1 in ApoE4-expressing neuronal cells 23 and a murine AD model. DDL-218 increased the transcription factor NFYb resulting in 24 upregulation of PRMT5. Mechanistic and modeling studies show that...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060379 | Pride
Sirtuin 1 Prmt5 Nfyb Sirt1 Sirt1 enhancer Memory Apolipoprotein e4 
UnknownHalf Disc Cartilage Tympanoplasty: A Newer Technique Versus Temporalis Fascia Tympanoplasty-Retrospective Analysis.
Not available
S-EPMC9411322 | biostudies-literature
UnknownUpdate on Existing Care Models for Chronic Kidney Disease in Low- and Middle-Income Countries: A Systematic Review.
Not available
S-EPMC8894943 | biostudies-literature
UnknownComparison of Gastric Alimetry® body surface gastric mapping versus electrogastrography spectral analysis.
Not available
S-EPMC10495352 | biostudies-literature
UnknownMumps Seroprevalence in Vellore, South India: A Community-Based Cross-Sectional Study.
Not available
S-EPMC12493236 | biostudies-literature
UnknownAlzheimer's disease biomarker utilization at first referral enhances differential diagnostic precision with simultaneous exclusion of Creutzfeldt-Jakob disease.
Not available
S-EPMC10862167 | biostudies-literature
UnknownAutotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.
Not available
S-EPMC6168304 | biostudies-literature
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