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GenomicsH4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription
Hormone-dependent gene expression requires dynamic and coordinated epigenetic changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon extensive chromatin remodeling and changes in histone modifications for the induction of hormone-responsive gene expression. Our previo...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-65886 | biostudies-arrayexpress
TranscriptomicsmRNA-seq of HCT116 RNF40 knockdown cells upon TNF-alpha stimulation
This analysis identifies genes which are affected upon RNF40 knockdown cells and/or TNF-alpha stimulation
ORGANISM(S): Homo sapiens 
2018-10-22 | E-MTAB-7197 | biostudies-arrayexpress
GenomicsChIP-seq for ARID1A in HCT116 cells
This study identifies binding sites for the chromatin remodeller subunit ARID1A in the HCT116 colorectal cancer cell line.
ORGANISM(S): Homo sapiens 
2019-06-24 | E-MTAB-7792 | biostudies-arrayexpress
TranscriptomicsATAC seq for L3.6pl cells: Parental and resistant to paclitaxel [PacR]
Identification of open chromatin regions in sensitive and resistant cells
ORGANISM(S): Homo sapiens 
2023-03-21 | E-MTAB-11730 | biostudies-arrayexpress
TranscriptomicsRNA seq in PacR L3.6pl cells
Identification of regulated genes in PacR L3.6pl
ORGANISM(S): Homo sapiens 
2023-03-21 | E-MTAB-11737 | biostudies-arrayexpress
TranscriptomicsleChRO-seq in L3.6pl (Parental and Paclitaxel-resistant)
Evaluate the nascent RNA-seq production in L3.6pl
ORGANISM(S): Homo sapiens 
2023-03-24 | E-MTAB-11744 | biostudies-arrayexpress
TranscriptomicsRNA seq of a pancreatic cancer patient-derived xenografts treated with Vehicle or Gemcitabine/Paclitaxel in mouse
Identification of regulated genes in Patient-derived xenografts from pancreatic cancer
ORGANISM(S): Homo sapiens 
2023-03-21 | E-MTAB-11739 | biostudies-arrayexpress
TranscriptomicsProteasome inhibition blocks estrogen-dependent gene transcription by decreasing histone H2B monoubiquitination in human breast cancer cells
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate est...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30931 | biostudies-arrayexpress
TranscriptomicsEstrogen-dependent gene expression in human breast cancer cells relies upon proteosome-dependent monoubiquitination of histone H2B
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate e...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31118 | biostudies-arrayexpress
TranscriptomicsleChRO-seq for 2 pancreatic cancer patient-derived xenografts treated with Vehicle or Gemcitabine/Paclitaxel in mouse
Evaluation of nascent RNA in PDX
ORGANISM(S): Homo sapiens 
2023-03-21 | E-MTAB-11740 | biostudies-arrayexpress
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