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TranscriptomicsWhole genome characterisation of chemoresistant ovarian cancer [Illumina_450K_Methylation]
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-65820 | biostudies-arrayexpress
UnknownSingle-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Not available
S-EPMC8064747 | biostudies-literature
TranscriptomicsB lymphocyte activation induces DNA methylation reprogramming and establishes a common epigenetic signature in memory B and plasma cell compartments [gene expression profiling]
DNA methylation profiling of human B cell populations representing a developmental series before and after immune activation. The B cells are derived from inflamed tonsils. The B cells were already activated in vivo in patients, therefore there was no need to stimulate the B cells after isolation. ...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-24863 | biostudies-arrayexpress
TranscriptomicsEaf7 identifies a native protein trimer linked to RNA polymerase-coupled nucleosome recycling
The NuA4 histone acetyltransferase (HAT) complex is required for gene specific regulation, cell cycle progression, and DNA repair. Dissection of the 13-subunit complex reveals that the Eaf7 subunit bridges Eaf5 with Eaf3, a H3K36me3-binding chromodomain protein, and this Eaf5/7/3 trimer is anchored ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-25 | E-MTAB-1780 | biostudies-arrayexpress
TranscriptomicsEarly postnatal expression data from mouse skeletal muscle stem cells
Satellite cells are the primary source of stem cells for skeletal muscle growth and regeneration. Since adult stem cell maintenance involves a fine balance between intrinsic and extrinsic mechanisms, we performed genome-wide chronological expression profiling to identify the transcriptomic changes i...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-65927 | biostudies-arrayexpress
UnknownEvaluating the risk of ovarian cancer before surgery using the ADNEX model: a multicentre external validation study.
Not available
S-EPMC4997550 | biostudies-literature
TranscriptomicsSystems-level analysis of N-starvation induced modifications of carbon metabolism in a Chlamydomonas starchless mutant
To understand the molecular basis underlying increased triacylglycerol accumulation in starchless Chlamydomonas mutants, we undertook comparative time course transcriptomics of sta6 (CC-4348), a cw strain purported to represent the parental STA6 strain (CC-4349), and 3 independent STA6 strains (STA6...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-10-24 | E-GEOD-51602 | biostudies-arrayexpress
GenomicsAssociation studies using the Metabochip array - Samples analysed by the WTCCC (1958 British Birth Cohort (58BC), Hypertension cohort (HT), Type 2 Diabetes Cohort (T2D) and Coronary Artery Disease (CAD) cohort)
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effectiv...
EGAS00000000115 | EGA
MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
MetabolomicsSerum-based metabolomics characterization of pigs treated with ractopamine
A study was performed to determine if serum-metabolomics could be used to establish a predictive tool for identifying ractopamine misuse in pigs. Ractopamine, a beta-agonist used as growth promoter in livestock, is with great controversy, and it has been forbidden in most countries worldwide. Howeve...
2017-06-12 | MTBLS384 | MetaboLights
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