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MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
ProteomicsWild-type and L317P mutant ARHGAP36 isoform 2 interactome
ARHGAP36 is an atypical Rho GTPase-activating protein (GAP) family member that drives both spinal cord development and tumorigenesis, acting in part through an N-terminal motif that suppresses protein kinase A and activates Gli transcription factors. ARHGAP36 also contains isoform-specific N-termina...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-18 | PXD019056 | Pride
Lc-msms Mouse Nih-3t3 
ProteomicsCorn stover variability drives differences in Rhodo conversion to SAF-Task 7-Okonkwo-2023-ABPDU
Discovery proteomics of R. toruloides strains' usage of corn stover variability study (ABPDU)
ORGANISM(S): Rhodotorula Toruloides (ncbitaxon:5286) 
2024-07-26 | MSV000095450 | MassIVE
ProteomicsCoordinate control of endoplasmic reticulum chaperone biosynthesis and peptide hormone secretion revealed by a β-cell model of Prader-Willi syndrome
Prader-Willi syndrome (PWS) is a multisystem disorder caused by loss of expression of a cluster of paternally-expressed, imprinted genes. Neonatal failure to thrive is followed by childhood-onset hyperphagia, obesity, neurobehavioral abnormalities, and hormonal deficits. Prior evidence from a mouse ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-11 | PXD034471 | Pride
Crispr/cas9  genomic imprinting  hormone secretion  metabolic disease  pancreatic islet 
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
ProteomicsCoordinate control of endoplasmic reticulum chaperone biosynthesis and peptide hormone secretion revealed by a β-cell model of Prader-Willi syndrome
Prader-Willi syndrome (PWS) is a multisystem disorder caused by loss of expression of a cluster of paternally-expressed, imprinted genes. Neonatal failure to thrive is followed by childhood-onset hyperphagia, obesity, neurobehavioral abnormalities, and hormonal deficits. Prior evidence from a mouse ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-11 | PXD037875 | Pride
Crispr/cas9  genomic imprinting  hormone secretion  metabolic disease  pancreatic islet 
ProteomicsCoordinate control of endoplasmic reticulum chaperone biosynthesis and peptide hormone secretion revealed by a β-cell model of Prader-Willi syndrome
Prader-Willi syndrome (PWS) is a multisystem disorder caused by loss of expression of a cluster of paternally-expressed, imprinted genes. Neonatal failure to thrive is followed by childhood-onset hyperphagia, obesity, neurobehavioral abnormalities, and hormonal deficits. Prior evidence from a mouse ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-11 | PXD037874 | Pride
Crispr/cas9  genomic imprinting  hormone secretion  metabolic disease  pancreatic islet 
UnknownTranscription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis.
Not available
S-EPMC2887718 | biostudies-literature
ProteomicsPeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements
Global proteomics datasets to study ash utilization by R. toruloides. PeakDecoder is a workflow for metabolite identification and accurate profiling in multidimensional LC-IM-MS-DIA measurements. It is available at https://github.com/EMSL-Computing/PeakDecoder
ORGANISM(S): Rhodosporidium Toruloides Np11 (ncbitaxon:1130832) 
2023-02-03 | MSV000091202 | MassIVE
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