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TranscriptomicsGlobal gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome [Set 2]
To understand the biological pathways involved in twin-twin transfusion syndrome (TTTS) by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from TTTS cases and controls revealed differential expression of 801 genes, which were significantly enri...
ORGANISM(S): Homo sapiens 
2013-05-28 | E-GEOD-47393 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome [Set 1]
To understand the biological pathways involved in twin-twin transfusion syndrome (TTTS) by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from TTTS cases and controls revealed differential expression of 801 genes, which were significantly enri...
ORGANISM(S): Homo sapiens 
2013-05-28 | E-GEOD-47392 | biostudies-arrayexpress
TranscriptomicsThe amniotic fluid transcriptome: a source of novel information about human fetal development
Amniotic fluid (AF) is a complex biological material that provides a unique window into the developing human. Residual AF supernatant contains cell-free fetal RNA. The objective of this study was to develop an understanding of the AF core transcriptome by identifying the transcripts ubiquitously pre...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-33168 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-05-28 | E-GEOD-47394 | biostudies-arrayexpress
TranscriptomicsExpression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls
In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in uncultured amniotic fluid supernatant samples. We identified individually differentially expressed genes via paired t-tests in the matched samples, and a set of di...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-16176 | biostudies-arrayexpress
TranscriptomicsFetal transcripts in maternal blood
The discovery of fetal mRNA transcripts in maternal circulation holds great promise for noninvasive prenatal diagnosis. To identify potential fetal biomarkers, we studied whole blood and plasma transcripts common to term pregnant women and their newborns but reduced or absent in the postpartum mothe...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53669 | biostudies-arrayexpress
TranscriptomicsGene expression changes in embryonic PECAM-1+ cells from Gata2 +9.5 enhancer targeted mice
We have generated a nonconditionall deletion of an E-box - GATA motif composite element from a putative enhancer 9.5 kb downstream of the Gata2 1S promoter. The mutation results in lethality at E13.5 to E14.5 with embryos exhibiting dectects in definitive hematopoiesis and vasculature integrity. H...
ORGANISM(S): Mus musculus 
2012-07-16 | E-GEOD-39300 | biostudies-arrayexpress
ProteomicsPlastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in Hidradenitis Suppurativa skin disease
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition often characterized by nodules, cysts, and tunneling sinus tracts. Incidence of HS varies by study, anywhere from 0.1% to 2% of the general population, and is increasing over time. Despite its common occurrence, the only FDA appr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD068006 | Pride
Nicastrin Skin Hidradenitis suppurativa Imaging 
TranscriptomicsAmniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome
Background: Turner syndrome, a common sex chromosome aneuploidy, has characteristics and malformations associated with the phenotype. Fetal amniotic fluid is a complex biological material that could contribute to the understanding Turner syndrome pathogenesis. Global gene expression analysis of Tu...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-GEOD-58435 | biostudies-arrayexpress
TranscriptomicsExpression profiles of amniotic fluid from human fetuses with Trisomy 18 and euploid controls
To understand the molecular mechanisms underlying the congenital anomalies observed in patients with Trisomy 18, we compared gene expression in uncultured amniotic fluid supernatant samples from second trimester fetuses with Trisomy 18 and from euploid controls. Analysis of differential expression u...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-25634 | biostudies-arrayexpress
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