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ProteomicsAutomated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-um spatial resolution
Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics and a mass spectrometry workflow to analyze tissue...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-04 | MSV000084421 | MassIVE
ProteomicsCoupling microdroplet-based sample preparation, multiplexed isobaric labeling, and nanoflow peptide fractionation for deep proteome profiling of tissue microenvironment
Existing spatially-resolved proteomics technologies cannot provide deep proteome coverage due to limited sensitivity and poor sample recovery. Herein, we seamlessly combined laser capture microdissection with a low-volume sample processing technology that includes a microfluidic device named microPO...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-25 | MSV000093925 | MassIVE
ProteomicsProtein expression patterns associated with sucrose-induced dysbiosis are conserved across taxonomically diverse oral microcosm biofilm models of dental caries.
The lesions of enamel caries can be considered as the outcome of dysbiotic changes in the biofilm community of supragingival dental plaque. Demineralization occurs as the cumulative outcome of repeated shifts towards a less diverse microbiota that produces and tolerates a low pH environment in tooth...
ORGANISM(S): Streptococcus mutans 19 
2016-01-04 | PXD003151 | Pride
Dental caries Metaproteomics Oral microbiome Galaxy-p Dysbiosis 
TranscriptomicsDifferential expression between Sh2b3 knockout and wild type mice
To validate the predicted Sh2b3 derived gene regulatory subnetwork using integrative network approach in human population study, we examined the gene expression levels of whole blood in WT (wild-type) and Sh2b3-/- mice by RNA sequencing, and identified the differentially expressed genes. RNA sequen...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-65348 | biostudies-arrayexpress
UnknownAllele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.
Not available
S-EPMC5720478 | biostudies-literature
UnknownGenetic comorbidities in Parkinson's disease.
Not available
S-EPMC3888265 | biostudies-literature
ProteomicsHanging-droplet sample preparation improves coverage for spatially-resolved proteomics
We developed a hanging drop (HD) method to improve the sample recovery for spatial proteomics by placing the nanowell chip in an upside-down direction during droplet-based sample preparation. Compared with the commonly-used sitting-drop (SD) method, the HD method can keep the tissue voxel away from ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-21 | MSV000089295 | MassIVE
UnknownDesign innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.
Not available
S-EPMC3481179 | biostudies-literature
UnknownRelevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study.
Not available
S-EPMC11292909 | biostudies-literature
UnknownMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Not available
S-EPMC3354734 | biostudies-literature
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