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A 70-gene signature has been shown in a single institution to have prognostic value in patients with node-negative breast cancer. The purpose of the present study was to validate the signature in independent patient samples.
ORGANISM(S): Homo sapiens 
Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognize...
ORGANISM(S): Homo sapiens 
Background: Recently a 76-gene prognostic signature able to predict distant metastases in lymph node-negative (N-) breast cancer patients was reported. The aims of this study conducted by TRANSBIG were to independently validate these results and to compare the outcome with clinical risk assessment. ...
ORGANISM(S): Homo sapiens 
Background: Histologic grade in breast cancer provides clinically important prognostic information. However, 30%-60% of tumors are classified as histologic grade 2. This grade is associated with an intermediate risk of recurrence and is thus not informative for clinical decision making. We examined ...
ORGANISM(S): Homo sapiens 
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