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ProteomicsRedundancy and Specialisation of Cyclin Dependent Kinases
Cyclin dependent kinases (CDKs) lie at the heart of eukaryotic cell division, with different CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs)1-3. However, the principles on which cyclin-CDKs organise the cell cycle are still contentious, with current theories suggesting that ei...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2022-03-22 | PXD029073 | Pride
Phosphoproteomics Fission yeast Tmt S. pombe 
ProteomicsCyclin-dependant kinase (CDK) orders the cell cycle via substrate specific thresholds
The appropriate ordering of the cell cycle events in eukaryoates is thought to be brought about by qualitative differences in the substrate specificity of multiple differentially expression Cyclin-CDK complexes. Our analysis of fission yeast supports an alternative quantitative model. Here we report...
ORGANISM(S): Schizosaccharomyces pombe 
2018-04-11 | PXD003598 | Pride
Mass spectrometry Cdk Silac Cell cycle S. pombe 
ProteomicsRapid acetylation of yeast Hsp70 mediates the cellular response to heat stress
Hsp70 is a highly conserved molecular chaperone critical for the folding of new and denatured proteins. While traditional models state that cells respond to stress by upregulating inducible HSPs, this response is relatively slow and is limited by transcriptional and translational machinery. Recent s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-24 | PXD015185 | Pride
Mass spectrometry Ptms Q-exactive Yeast Ssa1 Heat stress Acetylation 
GenomicsEGAD00000000114
Whole transcriptome sequence data from 18 ovarian clear-cell carcinoma samples and one TOV21G ovarian clear-cell carcinoma cell line
EGAD00000000114 | EGA
GenomicsARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
We have sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clear-cell carcinoma cell line and found somatic mutations in ARID1A (the AT-rich interactive domain 1A [SWI-like] gene) in 6 of the samples. ARID1A encodes BAF250a, a key component of the SWI–SNF chromati...
EGAS00000000075 | EGA
UnknownCommon genetic variants influence human subcortical brain structures.
Not available
S-EPMC4393366 | biostudies-literature
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
UnknownWho, if anyone, may benefit from a total hip arthroplasty after a displaced femoral neck fracture?: a post hoc subgroup analysis of the HEALTH trial.
Not available
S-EPMC9422900 | biostudies-literature
UnknownIdentification of common variants associated with human hippocampal and intracranial volumes.
Not available
S-EPMC3635491 | biostudies-literature
UnknownChallenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.
Not available
S-EPMC6909648 | biostudies-literature
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