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TranscriptomicsTranscription profiling of rat normal (control) and diabetic animals left ventricle heart tissue
Analysis of gene expression changes in the LV of a rodent heart that occur with uncontrolled diabetes; We used microarrays to detail the global changes that occur in gene expression in the LV of the heart as a result of STZ-induced diabetes. Experiment Overall Design: Male wistars were anaesthetised...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5606 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of null Pacman/Xrn1 mutant Drosophila L3 wing imaginal discs
Two pcm null alleles (pcm14 and pcm15) were sequenced alongside respective wild-type controls (wild-type 1 and wild-type 2). Each genotype was replicated 3 times. Read depth was 12-17 million reads per replicate. Total RNA was prepared from Drosophila L3 larval wing imaginal discs.
ORGANISM(S): Drosophila melanogaster 
2016-07-03 | E-MTAB-3789 | biostudies-arrayexpress
Transcriptomicspreparative changes in rat intestine and lung for birth
To identify genes important in fetal preparation for birth. Transcript profiling using microarray analysis was performed using lung and intestine RNA from a single animal from each of 10 litters at a given gestational age. Array experiments were performed by the Genomics CoreLab, Cambridge Comprehen...
ORGANISM(S): Rattus norvegicus 
2010-11-21 | E-GEOD-16849 | biostudies-arrayexpress
TranscriptomicsTranscruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-3790 | biostudies-arrayexpress
TranscriptomicsThe effect of Dis3 knockdown on miRNA expression in Drosophila wing imaginal discs.
We investigated the effect on miRNA expression in Drosophila melanogaster wing imaginal discs following the knockdown of the 3'-5' exoribonuclease Dis3.
ORGANISM(S): Drosophila melanogaster 
2015-06-01 | E-MTAB-3569 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of isolated rice gametes characterized by deep sequencing: Evidence for distinct sex-dependent chromatin and epigenetic states before fertilization
The formation of a zygote by the fusion of egg and sperm involves the two gametic transcriptomes. In flowering plants, the embryo sac embedded within the ovule contains the egg cell, while the pollen grain contains two sperm cells inside a supporting vegetative cell. The difficulties of collecting ...
ORGANISM(S): Oryza sativa Japonica Group 
2013-10-31 | E-GEOD-50777 | biostudies-arrayexpress
TranscriptomicsshRNA knockdown of ZMIZ1 in human T-cell Acute Lymphoblastic Leukemia cell line CEM
Human T-cell Acute lymphoblastic Leukemia cell line CEM was transfected with either shRNA against ZMIZ1 or scrambled shRNA. Four (non-paired) biological replicates of each condition had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. A supplementary Excel workb...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-32523 | biostudies-arrayexpress
TranscriptomicsLineage relationship in human dendritic cells
The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compa...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32400 | biostudies-arrayexpress
TranscriptomicsLineage relationship in human dendritic cells - cDNA arrays
The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compa...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32648 | biostudies-arrayexpress
TranscriptomicsGenome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifs
RNA-seq of ribosome depleted RNA extracted from SAOS-2 cells following treatment with either XRN1 siRNA or a scrambled siRNA control
ORGANISM(S): Homo sapiens 
2021-08-16 | E-MTAB-10808 | biostudies-arrayexpress
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