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GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WGS
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-4921 | biostudies-arrayexpress
Transcriptomics19 K14Cre; p53F/F mouse mammary tumor analysis
Tumor formation is in part driven by copy number alterations (CNAs), which can be measured using array Comparative Genomic Hybridization (aCGH). Identifying regions of DNA that are gained or lost in a significant fraction of tumor samples can facilitate identification of genes possibly related to th...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7794 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WGS part 2
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-5590 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WES
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-4917 | biostudies-arrayexpress
UnknownOlaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo.
Not available
S-EPMC7256072 | biostudies-literature
TranscriptomicsChronic exposure to fluticasone propionate shapes gene expression and modulates innate and adaptive activation pathways in human macrophages (INF)
Here we investigate how glucocorticoids affect the response to Interferon gamma in human macrophages. Total RNA obtained from monocyte-derived macrophages exposed to Interferon gamma presceding exposure to fluticasone propionate or left untreated.
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-49706 | biostudies-arrayexpress
TranscriptomicsChronic exposure to fluticasone propionate shapes gene expression and modulates innate and adaptive activation pathways in human macrophages (LPS)
Here we investigate how glucocorticoids affect the response to LPS in human macrophages. Total RNA obtained from monocyte-derived macrophages exposed to lipopolysacharide presceding exposure to fluticasone propionate or left untreated.
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-49709 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
ProteomicsPlasma membrane analysis of NAA60-deficient mouse mammary tumor cells
Analysis of plasma membrane enriched protein fractions from NAA60-proficient or deficient mouse mammary tumor cells.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-21 | PXD035143 | Pride
Plasma membrane isolation Naa60 
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
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