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TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse erythroblasts during erythroid differentiation
The I/11 and R10 erythroid progenitor cell line was cultivated in serum free medium (StemPro34) supplemented with Epo (0,5U/ml), SCF (100ng/ml) and dexamethasone (10-6M). To identify genes specifically regulated by Epo/SCF-induced polysome recruitment, cells were factor deprived for 4h and subsequen...
ORGANISM(S): Mus musculus 
2008-07-11 | E-MEXP-1689 | biostudies-arrayexpress
UnknownThe first step of peptide selection in antigen presentation by MHC class I molecules.
Not available
S-EPMC4321303 | biostudies-literature
UnknownInterleukin-4 alters early phagosome phenotype by modulating class I PI3K dependent lipid remodeling and protein recruitment.
Not available
S-EPMC3143135 | biostudies-literature
UnknownDapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
Not available
S-EPMC7523621 | biostudies-literature
UnknownRelapse in stage I(E) diffuse large B-cell lymphoma.
Not available
S-EPMC5947732 | biostudies-literature
MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
TranscriptomicsGene signature of adult mammary stem cells and mammary cancer stem cells (Affymetrix)
The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-...
ORGANISM(S): Mus musculus 
2013-08-29 | E-GEOD-40702 | biostudies-arrayexpress
TranscriptomicsGene signature of adult mammary stem cells and mammary cancer stem cells (RT_PCR)
The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-...
ORGANISM(S): Mus musculus 
2013-08-29 | E-GEOD-40704 | biostudies-arrayexpress
UnknownTrained Immunity in Primary Sjogren's Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype.
Not available
S-EPMC9289449 | biostudies-literature
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