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TranscriptomicsGene expression changes associated with progression of Irf8M-bM-^@M-^S/M-bM-^@M-^S CML-like disease into blast crisis after M-NM-2-catenin activation
Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics, we observed that compound constitutive activation of M-NM-2-catenin and deletion of Irf8 results in progression of CML-like disease into fatal bla...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-49054 | biostudies-arrayexpress
TranscriptomicsExpression data from HTR-8/Svneo side population (SP) and non-side population (NSP) cells
Immature cell populations, including stem cells and progenitor cells, can be found in M-bM-^@M-^\side-population (SP)M-bM-^@M-^] cells. Although SP cells isolated from some adult tissues have been reported elsewhere, isolation and characterization of human trophoblast SP cells remained to be reporte...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-61547 | biostudies-arrayexpress
TranscriptomicsMolecular crosstalk between hepatocytes and hepatic stellate cells.
Aim of the study was to characterize at a molecular level (changes in transcriptomes) the crosstalk between tumor hepatocytes and activated hepatic stellate cells (HSC) in liver cancer. This was adressed by using a coculture model system of HepaRG cell line (tumor hepatocytes, human), and LX2 cell l...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-32565 | biostudies-arrayexpress
UnknownOptogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases.
Not available
S-EPMC8341789 | biostudies-literature
TranscriptomicsGene expression analysis for CD56- T, NK, CD56+ T cells, and iNKT cells
A small subset of T cells also expresses kiler-cell immunoglobulin-like receptors (KIRs). We find that KIR+ T cells primarily reside in the CD56+ T population. However, little is known on how these cells are different from the conventional CD56- T, NK, and iNKT cells. We used microarray profiling to...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-47855 | biostudies-arrayexpress
UnknownDiagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries.
Not available
S-EPMC6675048 | biostudies-literature
ProteomicsDirect capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis by Cycliphostin & Cyclipostins analogs
Tuberculosis (TB) which is one of the deadliest infectious disease worldwide, is caused by the inhalation of the pathogenic bacteria Mycobacterium tuberculosis. Since many years now, the emergence of multiple (MDR), extensively (XDR) and totally (TDR) drug resistant strains amplifies the incidences ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Bacteria 
2022-09-20 | PXD034921 | Pride
Lc-msms  drug susceptibility  activity based-protein profiling  proteomic analysis  biochemical characterization  3d structure 
TranscriptomicsBile acids promote adenocarcinoma in a novel transgenic mouse model of BarrettM-bM-^@M-^Ys esophagus
Esophageal adenocarcinoma (EAC) has the fastest increase of any cancer in the US and Europe, and arises in the setting of BarrettM-bM-^@M-^Ys esophagus (BE), defined by replacement of normal squamous epithelium with columnar intestinal-like epithelium. BE is thought to result from chronic esophagea...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-24931 | biostudies-arrayexpress
UnknownS227: INITIAL SAFETY DATA FROM THE PHASE 3 POLAR BEAR TRIAL IN ELDERLY OR FRAIL PATIENTS WITH DIFFUSE LARGE CELL LYMPHOMA, COMPARING R-POLA-MINI-CHP AND R-MINI-CHOP
Not available
S-EPMC10428412 | biostudies-literature
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
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