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GenomicsGenome-wide mapping of MYCN binding in neuroblastoma cells
To identify the MYCN transcription factor binding sites across the genome, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using anti-MYCN and anti-IgG antibodies on a MYCN-amplified NB cell line, SK-N-BE(2)-C. Identification of MYCN binding in neuroblastoma cells.
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-72640 | biostudies-arrayexpress
TranscriptomicsEffects of MYCN knockdwon on miRNA expression in neuroblastoma cells
Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN To identify MYCN-associated miRNAs, we carried out a small RNA-seq on MYCN knockdown in SK-N-BE(2)-C cells to profile the miRNA expression.
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-72721 | biostudies-arrayexpress
TranscriptomicsExpression profiles of microRNAs in gastric cancer
We analyzed expression profiles of microRNAs from 22 paired gastric cancer and normal tissues and identified differentially expressed microRNAs. RNA from paired normal and tumor specimens in 22 gastric cancer patients were extracted and treated for microRNA microarray analysis.
ORGANISM(S): Homo sapiens 
2011-04-21 | E-GEOD-28700 | biostudies-arrayexpress
TranscriptomicsThe downstream gene expression of AnxA4 in AGS cells
AnxA4 expression is increased in H. pylori associated tumors. Moreover, in renal-cell cancer, AnxA4 increases tumor cell dissemination and promotes cell migration, and in colorectal cancer, it is identified as a potential diagnostic marker. How AnxA4 might be involved in tumorgenesis has remained un...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-33620 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteome of ecto-ATP synthase blockade in lung cancer cells
ATP synthase is crucial for ATP synthesis in living cells. Recently, ATP synthase was found not only in mitochondria but also on the extracellular surface, named as ectopic ATP synthase (ecto-ATP synthase). ATP synthase inhibitor is a potential drug candidate to fight cancer by blocking the ecto-ATP...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD000696 | Pride
Lung cancer cells Phosphoproteome Ecto-atp synthase 
ProteomicsPhosphoproteome of ecto-ATP synthase blockade in tumor xenograft tissues
ATP synthase is crucial for ATP synthesis in living cells. Recently, ATP synthase was found not only in mitochondria but also on the extracellular surface, named as ectopic ATP synthase (ecto-ATP synthase). ATP synthase inhibitor is a potential drug candidate to fight cancer by blocking the ecto-ATP...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD000701 | Pride
Phosphoproteome Tumor xenograft Ecto-atp synthase 
ProteomicsTargeting the E2F1/GAS5/p53 Axis as a Potential Therapeutic Strategy for Gefitinib-Resistant Lung Cancer
Lung cancer is one of the most common and fatal cancer worldwide. There are two major types of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Recently, gefitinib, a small molecule, which target tyrosine kinase, has been regarded as the first-line treatment in NSCL...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD013139 | Pride
Lung cancer Ectopic atp synthase Lncrna-interactomics Gefitinib resistance 
ProteomicsTemporal Phosphoproteome Dynamics Reveals the Role of ATP Synthase Inhibitor Citreoviridin in Gefitinib-resistant Lung Cancer Cells
Non-small cell lung cancer is the leading cause of cancer death worldwide. Gefitinib, epidermal growth factor receptor tyrosine kinase inhibitor, is the first-line treatment of NSCLC, however, many patients eventually become resistant and experience progressive disease. Therefore, development of eff...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD010767 | Pride
Lung cancer Ectopic atp synthase Gefitinib resistance Phosphoproteomics 
ProteomicsPhosphoproteome of Tanshinone IIA treatment in Human gastric cell line AGS
Gastric cancer is one of the world common causes of cancer death. Many people have suffered, but yet therapeutic methods found. May studies have showedthat Tanshinone IIA, a diterpenequinone, which extracted from the traditional herbal medicine Danshen (Salvia miltiorrhiza),has potential against man...
ORGANISM(S): Homo sapiens (Human) 
2020-03-18 | PXD005093 | Pride
Phosphoproteome Tanshinone iia Human gastric cell line ags Dimethyl labeling Hydroxy acid-modified metal oxide chromatography Strong cation-exchange chromatography fractionation Lc-ms/ms 
ProteomicsProteome of silenced minichromosome maintenance protein 2 with siRNA on non-small cell lung cancer H1299 cells
Lung cancer is the leading cause of cancer-related mortality. The two main lung cancer types are small cell lung cancer (SCLC) and non-SCLC (NSCLC), where NSCLC comprises about 80-85% of all lung cancer. Despite the introduction of improved treatments, the overall survival rate of lung cancer patien...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003743 | Pride
Non small cell lung cancer h1299 cells Rna interference Proteome Minichromosome maintenance protein 2 Itraq Lc-ms/ms 
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