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ProteomicsProteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE-/- mice exposed to diesel exhaust particles
Air pollution is an environmental risk factor linked to multiple human diseases including cardiovascular diseases (CVDs). While particulate matter (PM) emitted by diesel exhaust damages multiple organ systems, heart disease is one of the most severe pathologies affected by PM. However, the in vivo e...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-09 | PXD045029 | Pride
Platelet Diesel exhaust particles Tgfβ Heart fibrosis Proteomic analysis 
ProteomicsLysine acetylation of the housekeeping sigma factor enhances the activity of RNA polymerase holoenzyme
Protein lysine acetylation is one of the abundant post-translational modifications in eukaryotes, but found in prokaryotes as well. Despite the evidence of the lysine acetylation in the prokaryotic RNA polymerases (RNAPs), its function remains unrevealed. We revealed that the housekeeping sigma fact...
ORGANISM(S): Streptomyces venezuelae 
2020-05-27 | PXD015174 | Pride
Sigma factor Lysine acetylation Rna polymerase Transcription 
ProteomicsnextPP for chromosome-based proteomic research using neXtProt and GENCODE databases
In this study, we introduce a streamlined pipeline using customized and concatenated GENCODE and neXtProt databases with controlled false discovery rate (FDR) for finding GENCODE ASVs and missing proteins while mapping onto single amino acid variants (SAAVs) from Hippocampal dataset.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-07-25 | MSV000081385 | MassIVE
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