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UnknownPhase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas.
Not available
S-EPMC3867644 | biostudies-literature
TranscriptomicsTranscription profiling of human fetal cerebellum, heart, cerebrum, and cerebrum derived astrocyte cell line from trisomy 21 and trisomy 13 samples
Gene expression was measured in trisomy 21 and trisomy 13 human fetal samples. For TS21, regions assayed were cerebrum, cerebellum, heart, and cerebrum-derived astrocyte cell lines.
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1397 | biostudies-arrayexpress
GenomicsHoxc9 ChIP-seq in differentiating motor neurons
The expression of v5-tagged Hoxc9 is induced and ChIP-seq is used to profile genome-wide occupancy in differentiating motor neurons The differentiation of ventral motor neurons is induced by treating embryonic stem cell cultures with retinoic acid and hedgehog signaling. Here, ChIP-seq is used to pr...
ORGANISM(S): Mus musculus 
2010-09-08 | E-GEOD-21812 | biostudies-arrayexpress
ProteomicsReduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging
Low complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized,...
ORGANISM(S): Caenorhabditis elegans 
2017-01-16 | PXD003451 | Pride
Caenorhabditis elegans Itraq Quantification Aging Insulin Aggregation 
UnknownThe BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
Not available
S-SCDT-10_1038-S44319-025-00374-Z | biostudies-other
ProteomicsEstrogen Receptor Mutant Coregulator
Biotinylated 4xERE-containing DNA immobilized on streptavidin beads used to pulldown proteins recruited by unliganded WT ER-alpha versus Y537S, D538G, or ESR1-YAP1 fusion proteins from HeLa S3 human cell nuclear extracts.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-02-08 | MSV000080536 | MassIVE
TranscriptomicsMecp2: an unexpected regulator of macrophage gene expression and function [RNA-Seq]
Mutations in methyl-CpG-binding protein 2 (MeCP2), a major epigenetic regulator, are the predominant cause of Rett syndrome, an X-linked neurodevelopmental disorder. We previously found that Mecp2-null microglia are functionally impaired, and that engraftment of wild-type monocytes into the brain of...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-66211 | biostudies-arrayexpress
ProteomicsLongitudinal proteomic analysis of influenza HA-reactive IgG antibody repertoire over multiple years and repeated vaccinations
Longitudinal proteomic analysis of H1N1 A/California/7/2009 (CA09) hemagglutinin (HA)-reactive serum IgG antibody repertoire over 5 years and multiple (yearly) vaccinations (both pre- and post-vaccination samples) in a donor. Dataset consists of steady-state (pre-vaccination at day 0) and peak-respo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-08 | MSV000083120 | MassIVE
ProteomicsInfluenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans
Proteomic analysis of serum IgG antibody repertoire against influenza vaccine H1 (H1N1 A/California/7/2009) and H3 (H3N2 A/Texas/50/2012) in young, middle-aged, and elderly donors vaccinated with Fluzone 2013-14/14-15. Dataset consists of peak-response (days 21-28 post-vaccination) serum IgG samples...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086108 | MassIVE
TranscriptomicsCross-platform comparability of microarray data
To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray platforms and methods to accommodate this variability. RNA expression data were generated in seven labo...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2458 | biostudies-arrayexpress
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