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TranscriptomicsProfiling of normal human colonic epithelial cells according to their PTK7 surface abundance
Human mucosa was collected from two different individuals undergoing colectomy. After treatment with EDTA, colonic crypts were isolated and further dis-aggregated using Dispase. Next, cells were stained using antibodies directed against the extracellular domain of EpCAM, PTK7, CD11, CD31, and CD45. ...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-GEOD-68340 | biostudies-arrayexpress
TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
GenomicsHT-SELEX of recombinant C2H2 zinc finger domains of Sall4
To define the sequence preference of SALL4 C2H2 zinc finger domains, we performed SELEX coupled with high-throughput sequencing (HT-SELEX) using the purified SALL4 ZFC1, ZFC2 and ZFC4 domains combined with no protein control experiment. We re-sequenced the libraries from E-MTAB-9236 with very high c...
ORGANISM(S): synthetic construct 
2022-03-01 | E-MTAB-11484 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile changes by Prox1 expression in thyroid cancer cells
Human thyroid cancer cell line BCPAP was engineered for doxycyclin-mediated inducible expressoin of Prox1 and next generation sequcing was performed to study the transcriptional regulation by Prox1 BCPAP cells were infected with rTTA2 lentivirus. The resulting cell populations were then stably trans...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-75059 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human islets after in vitro expansion.
Pancreatic islet transplantation as a cure for type 1 diabetes (T1D) cannot be scaled up due to a scarcity of human pancreas donors. In vitro expansion of beta cells from mature human pancreatic islets provides an alternative source of insulin-producing cells. The exact nature of the expanded cells ...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-15543 | biostudies-arrayexpress
ProteomicsPKA signaling network-quantitative proteomics and phosphoproteomics
Classically, connections within a complex network can be identified through systematically removing its components one at a time and observing the resulting functional changes throughout the network. We applied this concept to identify the signaling network downstream from protein kinase A (PKA) in...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-23 | PXD005938 | Pride
Mouse Kindey Pka Proteomics Phosphorylation 
TranscriptomicsMecp2: an unexpected regulator of macrophage gene expression and function [RNA-Seq]
Mutations in methyl-CpG-binding protein 2 (MeCP2), a major epigenetic regulator, are the predominant cause of Rett syndrome, an X-linked neurodevelopmental disorder. We previously found that Mecp2-null microglia are functionally impaired, and that engraftment of wild-type monocytes into the brain of...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-66211 | biostudies-arrayexpress
UnknownSurface chemistry of rare-earth oxide surfaces at ambient conditions: reactions with water and hydrocarbons.
Not available
S-EPMC5361147 | biostudies-literature
UnknownEffect of Baicalin on Wound Healing in a Mouse Model of Pressure Ulcers.
Not available
S-EPMC9820804 | biostudies-literature
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