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MetabolomicsLipidomic characterization of Jurkat-derived T cell line in which the chaperonin complex CCT has been partially silenced
Not available
ORGANISM(S): Homo sapiens 
ST002185 | MetabolomicsWorkbench
MetabolomicsMetabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines
An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed. Here two T-cell lines were treated with an inhibitor...
2018-12-04 | MTBLS789 | MetaboLights
MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11844 | MetaboLights
TranscriptomicsTranscription profiling of human T cell leukaemia cell line Jurkat that were retrovirally transduced with constitutievely active forms of Notch to identify novel transcriptional targets of Notch signalling
In this study we aimed to identify novel transcriptional targets of Notch signalling in the T cell leukaemia cell line, Jurkat. RNA was prepared from Jurkat cells retrovirally transduced with an empty vector (Mock) or vectors containing constitutively active forms of Notch (N1deltaE or N3deltaE), an...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-MEXP-1744 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Jurkat T cell line and mouse thymocytes
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-SMDB-2194 | biostudies-arrayexpress
Transcriptomicsrole of miR-146a on Jurkat T cells
screenning the differentially expressed genes of Jurkat-FF3, Jurkat-miR146a, Jurkat-miR146a-sponge cell lines. To investigate the role of miR-146a on Jurkat T cells, we screened the differentially expressed genes of Jurkat-FF3 (as control), Jurkat-miR146a (as miR-146a overexpression cell line), Jur...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-21132 | biostudies-arrayexpress
ProteomicsMS-based arginine monomethylation study in Jurkat PRMT7 KO cells
Effects of Prmt7 genetic deletion to arginine monomethylation in Jurkat T-ALL cell line. Analysis was made using two different Prmt7 KO and one control cell lines.
ORGANISM(S): Homo Sapiens (human) 
2022-03-28 | PXD032819 | JPOST Repository
TranscriptomicsIdentification of differentially expressed genes upon shRNA knockdown of TAL1 and its regulatory partners in T-ALL cells (Jurkat)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcriptional program in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regu...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-29179 | biostudies-arrayexpress
TranscriptomicsExpression data from human Jurkat T cells exposed to 31 compounds
Compounds with direct immunotoxic properties, including metals, mycotoxins, agricultural pesticides and industrial chemicals, form potential human health risks due to exposure through food, drinking water, and the environment. Insights into the mechanisms of action are currently lacking for the majo...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Jurkat CF4+ T cells transfected with simian immunodeficiency virus Nef cells leads to a molecular profile of viral persistence and immune evasion.
Jurkat T cell line was transfected with SIV Nef controlled by an inducible promoter system. Nef was induced by addition of 10 micromolar pronasterone A and gene expression values were determined after 24 hrs. Control Jurkat cells were untransfected and treated with 10 micromolar pronasterone A and g...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4785 | biostudies-arrayexpress
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