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TranscriptomicsThe Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
Upon perturbations by RAS and by shBMAL, differential effects on the circadian phenotype were observed in wild type and Ink4a/Arf knockout MEFs which could be reproduced by modelling simulations and correlated with opposing cell cycle fate decisions.
ORGANISM(S): Mus musculus 
2017-12-08 | E-MTAB-5943 | biostudies-arrayexpress
ProteomicsDNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)
MutLα, a heterodimer consisting of MLH1 and PMS2, is a key player of DNA mismatch repair (MMR), yet little is known about its regulation. In this study, we used mass spectrometry to identify phosphorylated residues within MLH1 and PMS2. The most frequently detected phosphorylated amino acid was seri...
ORGANISM(S): Homo sapiens (Human) 
2018-08-28 | PXD009524 | Pride
Ck2 Phosphorylation Lynch syndrome Dna mismatch repair Mutlα Mlh1 
MetabolomicsCharacterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling
This study centered on detecting potentially anti-inflammatory active constituents in ethanolic extracts of Chinese Lonicera species by taking an UHPLC-HRMS-based metabolite profiling approach. Extracts from eight different Lonicera species were subjected to both UHPLC-HRMS analysis and to pharmacol...
2022-11-17 | MTBLS3112 | MetaboLights
TranscriptomicsMurine lung tumors- HER2(V659E) and KRAS(G12V) vs normal lung
Transcriptiional profling of 13 normal lung samples, 18 lung KRAS(G12V) tumor samples, and 18 lung HER2(V659E) tumor samples 13 normal lung samples, 18 lung KRAS(G12V) tumor samples, and 18 lung HER2(V659E) tumor samples hybridized against Stratagene universal mouse reference RNA with dye swap
ORGANISM(S): Mus musculus 
2009-11-30 | E-GEOD-18784 | biostudies-arrayexpress
UnknownImproving Breast Cancer Surgical Treatment Decision Making: The iCanDecide Randomized Clinical Trial.
Not available
S-EPMC5946719 | biostudies-literature
GenomicsFgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of Trophoblast Stem Cells
Derivation and maintenance of TS cells depends on the presence of Fgf signalling. Numerous gene knock-out experiments identified the mitogen activated kinase Mek/Erk branch of the Fgf signalling pathway as predominantly active in both TS cells and extraembryonic ectoderm. Therefore, we tested change...
ORGANISM(S): Mus musculus 
2015-08-18 | E-MTAB-3565 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spleens from dual specificity phosphatase-1 (DUSP1) deficient and wild type mice to demonstrate a specific regulatory role of DUSP1 on a subset of LPS-induced genes that control the outcome of endotoxin shock.
Activation of the Mitogen activated protein kinase (MAPK) cascade following Toll-like receptor (TLR) stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we iden...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3565 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
UnknownAminoacid functionalised magnetite nanoparticles Fe<sub>3</sub>O<sub>4</sub>@AA (AA = Ser, Cys, Pro, Trp) as biocompatible magnetite nanoparticles with potential therapeutic applications.
Not available
S-EPMC11528115 | biostudies-literature
TranscriptomicsTranscriptional profiling by array to study the effect of adenoviruses encoding the FLAG epitope or full-length antisense sequence to Atf3 on transcriptional regulation in rat cardiac myocytes
Cardiomyocytes, the terminally-differentiated contractile cells of the heart, undergo hypertrophic growth in response to endothelin-1. This is associated with changes in mRNA expression of immediate early genes (IEGs). Atf3 is a member of the ATF/CREB family transcription factors which bind as dim...
ORGANISM(S): Rattus norvegicus 
2012-10-01 | E-MEXP-3392 | biostudies-arrayexpress
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