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TranscriptomicsTranscription profiling of Foxa2 knock-outs in mice to better define the role of this gene in glucose homeostasis
Study to further characterize the genetic and functional consequence of the beta cell-specific ablation of Foxa2 (hepatocyte nuclear factor 3 beta, HNF-3b) in mice to better define the role of this gene in glucose homeostasis. The study involved 8 two-channel assays on UPenn Mouse PancChip 4.0, each...
ORGANISM(S): Mus musculus 
2006-06-30 | E-CBIL-13 | biostudies-arrayexpress
TranscriptomicsChIP-Chip and SACO Analysis of Pdx-1 binding in NIT-1 Insulinoma Cells
The BCBC Promoter Chip 5B was used to identify genomic targets of Pdx-1 binding. Genomic DNA from mouse NIT-1 insulinoma cells was immunoprecipitated with a Pdx-1 Antibody, PCR amplified, and labeled to the chip. All hybridizations were versus a common reference sample which was a labeled IgG IP. ...
ORGANISM(S): Mus musculus 
2014-11-21 | E-MTAB-3126 | biostudies-arrayexpress
GenomicsMetabolic Transcription Factors Mediate Conserved Functions Largely via Species-Specific Binding Regions
The winged helix protein FOXA2 and the nuclear receptor PPARg are highly conserved, regionally-expressed transcription factors that regulate networks of genes controlling complex metabolic functions. Cistrome analysis for FOXA2 in mouse liver and PPARg in mouse adipocytes has previously produced co...
ORGANISM(S): Homo sapiens 
2011-04-06 | E-GEOD-25836 | biostudies-arrayexpress
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