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GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
MetabolomicsDeciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic ...

2021-08-03 | MTBLS981 | MetaboLights
GenomicsH2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation
Chromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear. We show that H2A.Z is highly enriched at promoters and enhancers and is required for both efficient self-renewa...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-34483 | biostudies-arrayexpress
UnknownComparative efficacy of various CHIs combined with western medicine for non-small cell lung cancer: A bayesian network meta-analysis of randomized controlled trials.
Not available
S-EPMC9686447 | biostudies-literature
TranscriptomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (ChIP-chip and MeDIP-chip)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26827 | biostudies-arrayexpress
ProteomicsSystematic Proteomics Revealed The mechanism of How Long-term Tibetan Buddhist Meditation Enhanced Cardiovascular Protection
The difficulty to obtain data from whom uninterruptedly practice meditation over many years, and lacking of advanced analysis methods significantly hinder the comprehensive understanding of molecular mechanisms underlying meditation. This study aimed to address this issue.Accordingly, we recruited 8...
ORGANISM(S): Homo Sapiens 
2018-09-27 | PXD057418 |
TranscriptomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (mRNA)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26830 | biostudies-arrayexpress
UnknownSlight acceleration in podocyte mRNA loss in preterm-born children aged 3-5 years.
Not available
S-EPMC12727743 | biostudies-literature
UnknownCo-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila.
Not available
S-EPMC4316170 | biostudies-literature
GenomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (ChIP-Seq)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26832 | biostudies-arrayexpress
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