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TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, expression
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19360 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 2
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19382 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 1
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19381 | biostudies-arrayexpress
TranscriptomicsMouse T-cell lymphomas induced by irradiation at different ages
Children are considered more sensitive to radiation-induced cancer than adults, yet any differences in genomic alterations associated with age at exposure and their underlying mechanisms remain unclear. We analyzed the mutation of key tumor suppressor genes in T-cell lymphomas arising after weekly i...
ORGANISM(S): Mus musculus 
2015-11-12 | E-GEOD-63349 | biostudies-arrayexpress
TranscriptomicsBiallelic and complicated inactivation of Pten in radiation-induced mouse thymic lymphomas
Inactivation of Pten occurs by multiple mechanisms including epigenetic silencing, point mutations, insertion, and deletion, which are tissue dependent. Although frequent loss of heterozygosity around Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induce...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17751 | biostudies-arrayexpress
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
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