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ProteomicsNovel calcium-binding sites in the acylated segment control the folding and membrane penetration of RTX toxins
The Repeats in ToXin (RTX) domain of RTX cytolysins harbors numerous hexacoordinated Ca2+-binding sites that facilitate cooperative and vectorial folding of the RTX β-rolls. Recent study identified Ca2+-binding sites in the acylated N-terminal extension of the RTX domain of Bordetella pertussis aden...
ORGANISM(S): Bordetella pertussis 
2026-04-22 | PXD058094 | Pride
Membrane penetration H/d exchange Rtx toxin Folding Calcium binding site Acylated segment 
ProteomicsA conserved tryptophan in the acylated segment controls β2- integrin-independent cell penetration of RTX toxins
The post-translationally acylated Repeats in ToXins (RTX) leukotoxins, such as the adenylate cyclase (CyaA) or α-hemolysin (HlyA), bind β2-integrins of leukocytes, but also penetrate cells lacking these receptors. We show that the indole of conserved tryptophans within the acylated segments, e.g. W8...
ORGANISM(S): Bordetella pertussis 
2023-07-11 | PXD041207 | Pride
Hydrogen-deuterium exchange Tryptophan residue Adenylate cyclase toxin Α-hemolysin Trp-pro interaction Thermal stability Β2-integrins Rtx toxin Acylated segment Cytotoxicity 
ProteomicsNovel activity assay for botulotoxin A1 detection using functionalized chips and matrix-assisted laser desorption/ionization mass spectrometry
Botulinum neurotoxins (BoNTs) are a group of neurotoxins produced by Clostridium bacteria. Their effect on neuro-muscular connections through cleaving proteins of the SNARE complex results in blocking acetylcholine signal transduction. To prevent external intoxication by BoNT, analysis of potential ...
ORGANISM(S): Clostridium botulinum 
2025-03-21 | PXD058240 | Pride
Neurotoxin Maldi-tof Activity Botulinum Endopep Assay 
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