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ProteomicsComprehensive Profiling of Mammalian Tribbles Interactomes Implicates TRIB3 in Gene Repression
The three human Tribbles (TRIB) pseudokinases have been implicated in a plethora of signaling and metabolic processes linked to cancer initiation and progression and can potentially be used as biomarkers of disease and prognosis. While their modes of action reported so far center around protein–prot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD030404 | Pride
Tribbles  proteomics  interactome  breast cancer 
ProteomicsThe pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo
Objective: In vivo studies in humans and mice have implicated the pseudokinase Tribbles 3 (TRIB3) in various aspects of energy metabolism. Whilst cell-based studies indicate a role for TRIB3 in adipocyte differentiation and function, it is unclear if and how these cellular functions may contribute t...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-26 | PXD046703 | Pride
Tribbles  adipocyte  omics analyses  metabolism 
ProteomicsTrib3 modulates PPAR-mediated growth inhibition by interfering with the MLL complex in breast cancer cells
Dysregulation of pathways due to mutations on oncogenes or tumor suppressors that leads to aberrant expression or activity of proteins is the most well understood mechanism that drives cancer initiation and progression. TRIB3, a member of the Tribbles family of pseudokinases, is often found dysregul...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD036341 | Pride
Mll complex Breast cancer cells Trib3 Ppar 
ProteomicsPPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
The peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with PPARγ function cause lipodystrophy. Structural studies indicate that PPARγ domains engage in several intra- and inter-moleuclar interactions; however, how ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-08 | PXD036589 | Pride
Human Pparg Adipocyte differentiation 
TranscriptomicsCD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes and is regulated by adipocytes
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased i...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-39534 | biostudies-arrayexpress
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