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GenomicsDynamic changes in E protein activity orchestrate germinal center and plasma cell development [ChIP-Seq]
Humoral immunity requires the generation of high-affinity antibodies, which involves the generation of germinal centres (GC) promoting class switch and affinity maturation of antigen-specific B cells, and the differentiation of long-lived plasma cells. This multi-layered process is tightly controlle...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-72828 | biostudies-arrayexpress
TranscriptomicsDynamic changes in E protein activity orchestrate germinal center and plasma cell development [RNA-Seq]
Humoral immunity requires the generation of high-affinity antibodies, which involves the generation of germinal centres (GC) promoting class switch and affinity maturation of antigen-specific B cells, and the differentiation of long-lived plasma cells. This multi-layered process is tightly controlle...
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-72831 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells
Regulatory T (Treg) cells are required for peripheral tolerance. Recent evidence indicates that Treg cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with T helper differentiation. We demonstrate that expression of ...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-27143 | biostudies-arrayexpress
TranscriptomicsIRF4/BATF and interleukin-33 orchestrate development and maintenance of adipose tissue resident regulatory T cells
To understand the differentiation of effector Tregs in more detail, we have performed transcriptional profiling of central Tregs and effector Tregs, based on Blimp1 expression. We performed RNA-sequencing of Foxp3+ regulatory T cells, comparing Blimp1/GFP+ and Blimp1/GFP- cells Three biologically in...
ORGANISM(S): Mus musculus 
2014-12-11 | E-GEOD-62535 | biostudies-arrayexpress
GenomicsThe transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells [ChIP-seq]
We demonstrate that transcription factor IRF4 is induced in a T cell receptor (TCR) affinity-dependent manner and functions as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulates the expression of key molecules required for aerobic glycolysis of effector T cells...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-49930 | biostudies-arrayexpress
TranscriptomicsThe transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells [RNA-seq]
We demonstrate that transcription factor IRF4 is induced in a T cell receptor (TCR) affinity-dependent manner and functions as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulates the expression of key molecules required for aerobic glycolysis of effector T cells...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-49929 | biostudies-arrayexpress
GenomicsThe transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-49931 | biostudies-arrayexpress
TranscriptomicsscRNA- and TCR-Seq of mouse T cells from WT and TIGIT KO mice at steady state and upon LCMV infection
The experimental setup is aimed at understanding the function of the co-inhibitory receptor TIGIT in T cells. We compared sorted T cells (CD8+ T cells, CD4+Foxp3- T cells, CD4+Foxp3+ Tregs) from WT and TIGIT KO mice at steady state (naive mice) and following LCMV infection (day 10, LCMV clone 13). C...
ORGANISM(S): Mus musculus 
2025-09-14 | E-MTAB-14959 | biostudies-arrayexpress
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