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TranscriptomicsGene Expression Analysis of PDAC tumors
Analysis of myofibroblast ablation at the gene expression level of PDAC tumors. Total RNA optained from pancreas of PDAC mice with and without aSMA myofibroblast ablated In addition, late stage aSMA ablated mice were treated with anti-CTLA4 treatment
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-52812 | biostudies-arrayexpress
TranscriptomicsThe role of cancer exosomes in non-tumorigenic cells
The goal of this study is to report that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC Loading Complex (RLC) and display cell-independent capacity to process precursor microRNAs (pre-miRNAs) into mature miRNAs. Pre-miRNAs, along with Dicer, AGO2, and TRBP, ar...
ORGANISM(S): Homo sapiens 
2014-08-27 | E-GEOD-60713 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Cancer-Associated Fibroblast (CAF) compared to Normal Fibroblast (NF) [microarray]
Analysis of differentially expressed genes in CAF associated with PDAC vs NF Total RNA obtained from PDAC CAF and NF samples
ORGANISM(S): Mus musculus 
2014-06-18 | E-GEOD-53524 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Cancer-Associated Fibroblast (CAF) compared to Normal Fibroblast (NF) [RNA-seq]
Analysis of differentially expressed genes in CAF associated with PDAC vs NF. Genetically engineered mice with spontaneous pancreas cancer were generated. Their genotype is Ptfa-cre/+:LSL KrasG12D/+;Tgfrb2flox/flox. Cancer associated fibroblasts were expanded in vitro from the tumors of these mice (...
ORGANISM(S): Mus musculus 
2014-06-18 | E-GEOD-55870 | biostudies-arrayexpress
TranscriptomicsPGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
The study aimed to analyse the transcriptome of mouse cancer cells while in primary tumor, in circulation and after homing to metastatic site. The model used here is the 4T1 cancer cell orthotopic model. GFP-labeled 4T1 breast cancer cells were orthotopically implanted in the mammary pads of mice. I...
ORGANISM(S): Mus musculus 
2014-09-23 | E-GEOD-37344 | biostudies-arrayexpress
TranscriptomicsS100A4+ Stromal Cells from Normal Lung vs. Metastatic Lung
Analysis of S100A4+ stromal cells at the gene expression level in physiological setting versus metastatic setting. Total RNA was isolated from FACS-sorted S100A4+ stromal cells from normal lung of S100A4-GFP transgenic mice compared to FACS-sorted S100A4+ stromal cells from metastatic lung of 4T1 tu...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-31711 | biostudies-arrayexpress
TranscriptomicsExosomes miRNA array submission
MicroRNA microarray profilling analysis was performed on exosomes derived from 4T1 mammary epithelial cancer cells in two culture conditions, hypoxia and normoxia.
ORGANISM(S): Mus musculus 
2014-06-01 | E-MTAB-2361 | biostudies-arrayexpress
ProteomicsCirculating ACE2-expressing Extracellular Vesicles as an Innate Antiviral Response and A Decoy Therapy to Block Broad Strains of SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with 216 million cases and 4.5 million deathsas of September 2021.Thathas been exacerbated by mutated variants such as α, β, and with high infection rates and i...
ORGANISM(S): Homo Sapiens (human) 
2021-12-10 | PXD029662 | JPOST Repository
UnknownCDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC
Not available
S-SCDT-10_1038-S44318-026-00854-5 | biostudies-other
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