Sort   by:  
 Page size 
ProteomicsGeneralizable direct protein sequencing with InstaNexus
Critical protein therapeutics, such as antibodies and nanobodies, are often not encoded in reference genomes, limiting their accurate characterization via standard proteomics. Current methods rely on indirect inference, fragmented outputs, and labor-intensive workflows, which hinder functional insig...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-02-23 | PXD066160 | Pride
ProteomicsCLIPPER 2.0: Peptide level annotation and data analysis for positional proteomics
Positional proteomics methodologies have transformed protease research and have brought mass spectrometry (MS)-based degradomics studies to the forefront of protease characterization and system-wide interrogation of protease signaling. Considerable advancements in sensitivity and throughput of liqui...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD047261 | Pride
Lc-ms Post-translational modification Positional proteomics Computational proteomics Degradomics 
ProteomicsInstaNovo enables diffusion-powered de novo peptide identification in large scale proteomics experiments
Bottom-up mass spectrometry-based proteomics is challenged by the task of identifying the peptide that generates a tandem mass spectrum. Traditional methods that rely on known peptide sequence databases are limited and may not be applicable in certain contexts. De novo peptide sequencing, which assi...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD044934 | Pride
Peptidomics Machine learning Protein sequencing Proteomics De novo sequencing 
ProteomicsBroad and specific anti-defense genes in bacteriophage genomes
Bacteria and bacteriophages have been engaged in a relentless evolutionary arms race, driving a rapid evolution of bacterial defense mechanisms and leading to their scattered distribution across genomes. We hypothesized that the variability in defense systems presence in bacterial genomes leads to e...
ORGANISM(S): Pseudomonas aeruginosa AES-1R Bacteria 
2026-02-23 | PXD063439 | Pride
Bacterial immunity Defense systems Bacteriophage Dia proteomics 
ProteomicsMulti-omics analysis reveals the impact of influenza A virus host adaptation on immune signatures in pig tracheal tissue
Influenza A virus (IAV) infection is a global respiratory disease, which annually leads to 3-5 million cases of severe illness, resulting in 290,000-650,000 deaths. Additionally, during the past century, four global IAV pandemics have claimed millions of human lives. The epithelial lining of the tra...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-08-08 | PXD052229 | Pride
Immune regulation Influenza a virus Global proteomics Host adaptation Rna-seq Host metabolism 
ProteomicsInstaNovo-P T47D cell phosphoproteomics
Phosphorylation, a vital post-translational modification (PTM), plays a central role in cellular signaling and disease mechanisms. Mass spectrometry-based phosphoproteomics is widely used for system-wide characterization of phosphorylation events. However, traditional methods struggle with accurate ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD062859 | Pride
Breast cancer Growth factor Phosphoproteomics 
ProteomicsHigh-throughput and high-sensitivity biomarker monitoring in body fluid by fast LC SureQuant™ IS targeted quantitation
Targeted proteomics methods have been greatly improved and refined over the last decade and are becoming increasingly the method of choice in protein and peptide quantitative assays. Despite the tremendous progress in targeted proteomic assays, they still suffer from inadequate sensitivity for lower...
ORGANISM(S): Homo Sapiens 
2025-10-07 | PXD032305 | panorama
ProteomicsLongitudinal evaluation of biomarkers in wound fluids of venous leg ulcers treated with a protease-modulating wound dressing
Venous leg ulcers (VLU) represent a clinical challenge and impair the patient’s quality of life. Venous insufficiency is underlying the protracted healing. We report the protein expression pattern for biomarkers in VLU wound fluids and compare these with acute split-thickness wound fluids. Fifty-se...
ORGANISM(S): Homo Sapiens 
2023-08-22 | PXD025748 | panorama
Sort   by:  
 Page size