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UnknownDeciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Current molecular quantitative trait locus catalogs are mostly at bulk resolution and centered on Europeans. Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, host genetics, plasma proteomics and gut metagenomics from 235 J...
S-EPMC12339405 | biostudies-literature
UnknownLack of association between SLFN11 expression and treatment efficacy or survival outcomes in patients with pancreatic ductal adenocarcinoma.

Purpose

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA damage response and influence tumor sensitivity to c...
S-EPMC12064574 | biostudies-literature
UnknownUrinary Titin as a Non-Invasive Biomarker for Sarcopenia Sex Differences in Unresectable Digestive Malignancies: A Retrospective Cohort Study
Not available
S-EPMC12295692 | biostudies-literature
UnknownUltrasound-detected gastric changes related to zolbetuximab-induced emesis: a case series.

Background

Zolbetuximab prolongs survival in patients with claudin18.2 (CLDN18.2)-positive gastric cancer (GC) and gastroesophageal junction cancer. However, it is associated with an increased risk of emesis, and its underlying mechanism remains unclear.

Case presentation

This report ...
S-EPMC12699232 | biostudies-literature
UnknownApplication of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis.

Purpose

To investigate the sensitivity and specificity of herpes virus detection by nanopore metagenomic analysis (NMA) compared with multiplex polymerase chain reaction (mPCR)-positive and -negative controls.

Methods

This study included 43 patients with uveitis who had been screened ...
S-EPMC12013679 | biostudies-literature
UnknownDisulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.
Tumor-initiating cells (TICs) play a central role in tumor development, metastasis, and recurrence. In the present study, we investigated the effect of disulfiram (DSF), an inhibitor of aldehyde dehydrogenase, toward tumor-initiating hepatocellular carcinoma (HCC) cells. DSF treatment suppressed the...
S-EPMC3890271 | biostudies-literature
UnknownHitherto-Unnoticed Self-Transmissible Plasmids Widely Distributed among Different Environments in Japan.
Various conjugative plasmids were obtained by exogenous plasmid capture, biparental mating, and/or triparental mating methods from different environmental samples in Japan. Based on phylogenetic analyses of their whole-nucleotide sequences, new IncP/P-1 plasmids that could be classified into novel s...
S-EPMC9499019 | biostudies-literature
ProteomicsAnalysis of exosomes released from cancer-associated glycosphingolipid-expressing cancer cells
In order to study the mechanism by which GD3/GD2-containing EVs released from gliomas in the actions toward target cells, we performed proteome analysis of EVs with/without GD3/GD2.
ORGANISM(S): Homo Sapiens (human) 
PXD056795 | JPOST Repository
ProteomicsProteomic analysis of Cdkal1-KO mouse podocyte cell line
E11 murine kidney podocyte cell line was purchased from Cell Lines Service. Cells were cultured in RPMI medium (Wako) supplemented with 10% fetal bovine serum (Sigma) at 33°C and induced to differentiate by culture at 37°C for two weeks and 5% CO2. Cdkal1 knockout in the E11 cell line was performed...
ORGANISM(S): Mus Musculus (mouse) 
2025-11-11 | PXD057714 | JPOST Repository
UnknownQuantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.
Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell ...
S-EPMC11406184 | biostudies-literature
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