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ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
ProteomicsTotal and synaptosomal proteomic analysis
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-19 | MSV000091510 | MassIVE
UnknownTracing of the fecal microbiota of commercial pigs at five growth stages from birth to shipment.
The intestinal microbiota affect various physiological traits of host animals such as brain development, obesity, age, and the immune system. In the swine industry, understanding the relationship between intestinal microbiota and growth stage is essential because growth stage is directly related to ...
S-EPMC5902624 | biostudies-literature
ProteomicsA systematic proteogenomic approach to deciphering of the missing proteins: the example of newly uncovered NHERF1 function associated with human reproductive disorder
We propose and demonstrate a systematic approach designed to combine stringent criteria for claims of missing protein (MP) identification with extensive annotation as critical components of the discovery and functional validation of MPs.
ORGANISM(S): Homo sapiens (Human) 
2018-01-05 | PXD004723 | Pride
Human Placental tissues Lc-ms/ms 
ProteomicsInhibition of Alternative Complement Pathway May Cause Secretion of Factor B, Enabling an Early Detection of Pancreatic Cancer
This study aims to elucidate the cellular mechanisms underlying the secretion of factor B (CFB), recognized for its dual role as an early biomarker of pancreatic ductal adenocarcinoma (PDAC) and as the initiating substrate for the alternative complement pathway (ACP), a crucial component of the inna...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD047043 | Pride
Complement factor b Proteomics Adrenomedullin Alternative pathway Pancreatic ductal adenocarcinoma Cancer biomarker Complement factor h 
ProteomicsPhospho-tyrosine proteomic analysis in Ptprd-meB+/– mice
PTPδ, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPδ trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced mini-exo...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-01 | PXD053554 | Pride
Phospho-tyrosine proteomic analysis Ptprd-meb Lc-ms/ms 
MetabolomicsGNPS - MassIVE data submission of Taraxacum MSe data
LC-MSe data of 13 Taraxacum species (whole plant body) extracts for analyzing their chemical diversity, including 8 QC samples (mixture of all the samples in same conc.)
ORGANISM(S): Taraxacum Platycarpum (ncbitaxon:170727) Taraxacum Officinale (ncbitaxon:50225) Taraxacum Ohwianum Taraxacum Coreanum (ncbitaxon:1041103) Taraxacum Mongolicum (ncbitaxon:90037) 
2020-02-06 | MSV000084931 | GNPS
UnknownRegorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial.

Purpose

We evaluated the activity of regorafenib, an oral multikinase inhibitor, in advanced gastric adenocarcinoma.

Patients and methods

We conducted an international (Australia and New Zealand, South Korea, and Canada) randomized phase II trial in which patients were randomly assign...
S-EPMC5019744 | biostudies-literature
TranscriptomicsFunctional analysis of KAI1
We sequenced mRNA from mouse EML cell line under Kai1 knockdown or Kai1 overexpressing condition. KAI1 belongs to tetraspanin superfamily and is known as suppressor of tumor metastasis. Examination of mRNA levels in wildtype (WT) and KAI1 knockdown EML cells were generated by deep sequencing, in dup...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-56867 | biostudies-arrayexpress
UnknownCharacterization of Somatic Mutations in Air Pollution-Related Lung Cancer.
Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China attributed to severe air pollution generated by combustion of smoky coal, providing a uni...
S-EPMC4534757 | biostudies-literature
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