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TranscriptomicsDistinct STAT5 concentrations uniquely control establishment and differentiation of mammary epithelium during pregnancy
To dissect regulatory processes of cell proliferation and differentiation we generated mouse strains carrying any combination of the four Stat5 alleles, thus expressing STAT5 from 0 to 100%. RNA-Seq analyses revealed that different STAT5 levels activate specific genetic programs linked to cell proli...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-37646 | biostudies-arrayexpress
GenomicsHrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin [MNase-Seq]
We report that the Schizosaccharomyces pombe CHD remodeler, Hrp3, is a global regulator that drives higher-order chromatin structure and genomic stability. The loss of Hrp3 resulted in nucleosome perturbation across the chromosome, and the production of antisense transcripts in the hrp3M-bM-^HM-^F c...
ORGANISM(S): Schizosaccharomyces pombe 
2012-10-02 | E-GEOD-40451 | biostudies-arrayexpress
GenomicsImpact of STAT5 dosage and binding location on genetic and biological programs activated in mouse mammary epithelium during pregnancy.
The transcription factor STAT5 has long been recognized as an important mediator of prolactin induced mammary development during pregnancy. We have used mouse genetics and genome-wide analyses to determine how altering concentrations of STAT5A and STAT5B impacts different target promoters. Examinati...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-40930 | biostudies-arrayexpress
GenomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.
Signal Transducers and Activators of Transcription (STAT) 5A/B regulate cytokine-inducible genes upon binding to GAS motifs. It is not known what percentage of genes with GAS motifs bind to and are regulated by STAT5. Moreover, it is not clear whether genome-wide STAT5 binding is modulated by its co...
ORGANISM(S): Mus musculus 
2012-01-12 | E-GEOD-34986 | biostudies-arrayexpress
TranscriptomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
Stat5+/- mice were bred into the C57BL/6 background. Stat5+/- mice were intercrossed and mouse embryonic fibroblasts (MEFs) were isolated from 12.5-13.5-day WT or Stat5-/- fetuses. The retroviral-expression vector carrying a wild-type Stat5A gene based on an MSCV-IRES-GFP backbone (gift from Richard...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33688 | biostudies-arrayexpress
TranscriptomicsDisruption of H3K27me3 through loss of EZH1 and EZH2 accelerates progression of hepatosteatosis to fatal liver fibrosis
Although epigenetic mechanisms, such as specific histone modifications, control common and cell-specific genetic programs, a role for histone modifying enzymes in liver metabolism and disease has not been investigated. This report demonstrates that the combined loss of the histone methyltransferases...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53627 | biostudies-arrayexpress
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