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ProteomicsBacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
In this study, we characterized the proteomic composition of extracellular vesicles released from human THP-1 monocytes challenged with the pneumococcal pore-forming toxin, pneumolysin. We found that the vesicles shed from pneumolysin challenged cells are selectively enriched in key inflammatory hos...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD052436 | Pride
Human Monocytes Pneumolysin challenge Inflammation Streptococcus pneumoniae Lc-ms Exosome cargo 
UnknownData supporting the anticancer activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis Ehrenberg (1831).
Not available
S-EPMC5470600 | biostudies-literature
TranscriptomicsSaccharomyces cerevisiae deletion collections chemogenomic screen with sr7575
Growth assay in the presence of a toxic chemical (sr7575) that uses the barcoded collections of yeast gene deletions (haploid, diploid, DamP) to identify deletion strains that are hypersensitive to the drug. Two-condition experiment – growth of a pool of strains in the presence or absence of the d...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-09 | E-GEOD-60934 | biostudies-arrayexpress
TranscriptomicsS. coelicolor Wild Type R5- Medium Time-course Study
Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and physiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Although consistency between mRNA and proteins is often...
ORGANISM(S): Streptomyces coelicolor 
2010-06-11 | E-GEOD-7172 | biostudies-arrayexpress
UnknownProtein Set Transformer: a protein-based genome language model to power high-diversity viromics.
Not available
S-EPMC12705698 | biostudies-literature
TranscriptomicsS. coelicolor YSK3225 R5- Medium Time-course Study (Culture #1)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this stud...
ORGANISM(S): Streptomyces coelicolor 
2010-06-11 | E-GEOD-8108 | biostudies-arrayexpress
UnknownTunnel-floor entry continuous curvilinear capsulorhexis technique: Rhexis in a controlled and stable anterior chamber always.
Not available
S-EPMC9907313 | biostudies-literature
TranscriptomicsS. coelicolor M145 Time-course Study in R5- medium (Culture# 3)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this stud...
ORGANISM(S): Streptomyces coelicolor 
2010-06-11 | E-GEOD-8107 | biostudies-arrayexpress
TranscriptomicsS. coelicolor Wild Type Time-course Study in R5- medium (Culture#1)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this stud...
ORGANISM(S): Streptomyces coelicolor 
2010-06-10 | E-GEOD-8084 | biostudies-arrayexpress
MetabolomicsSequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 mth following their acute phase of infection to comprehensively profile and as...

2024-02-23 | MTBLS7337 | MetaboLights
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