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TranscriptomicsGenome-wide enrichment of Gcn5 and H3K18/H4K16 acetylation under physiological change of stress adaptation and stress recovery
The data provide information of Gcn5 enrichment, H3K18 and H4K16 acetylation level and Histone H3 density for 5 different physioloigcal conditions during stress adpatation and stress recovery (normal growth, during stress adaptation, after stress adaptation, under stress recovery, after stress rec...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-22 | E-GEOD-36600 | biostudies-arrayexpress
TranscriptomicsDeletion of Clr3 restores expression of a subset of genes in gcn5- mutant cells
Histone acetylation and deacetylation is important for gene regulation. The histone acetyltransferase, Gcn5, is a known activator of transcriptional initiation that is recruited to gene promoters. Here we map genome-wide levels of Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predom...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-24 | E-GEOD-13817 | biostudies-arrayexpress
TranscriptomicsKat2a regulates hippocampal memory formation [RNA-seq]
We sequenced mRNA from 24 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine transcriptome and the first CA1-transcriptome in response to environmental novelty under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control naM-CM-/ve (n...
ORGANISM(S): Mus musculus 
2014-07-16 | E-GEOD-53380 | biostudies-arrayexpress
TranscriptomicsKat2a regulates hippocampal memory formation [small RNA-seq]
We sequenced small RNAs from 12 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine miRNome under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control (n=6), C: Kat2a cKO naïve (n=6)
ORGANISM(S): Mus musculus 
2014-07-16 | E-GEOD-53427 | biostudies-arrayexpress
GenomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [mESCs_ChIPSEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67710 | biostudies-arrayexpress
GenomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_ChIPSEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67694 | biostudies-arrayexpress
TranscriptomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_RNASEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67715 | biostudies-arrayexpress
TranscriptomicsComparison of gene regulation by Gcn5 under KCl stress in S. cerevisiae and S. pombe
This is parallel comparison of gene regulation by Gcn5 in evolutionarily divergent yeasts S. pombe and S. cerevisiae. Our study showed Gcn5 is required for a similar spectrum of stress responses in both organisms, including the response to KCl. This DNA microarray studies is to find conserved or div...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-5218 | biostudies-arrayexpress
ProteomicsHuman KAT2A/B-acetylome MudPIT
Comprehensive identification of acetylated proteins targeted by the lysine acetyltransferases KAT2A (GCN5) and KAT2B (PCAF), in human cells. KAT2A/B-dependent acetylated proteins were identified by comparing acetylated proteins in whole cell extract of control cells and cells in which KAT2A and KAT2...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD004669 | Pride
Acetylation Non-histone targets Kat2a(gcn5) Centrosome duplication Kat2b (pcaf) Plk4 
TranscriptomicsTranscription profiling by array of Gcn5 and Ada2a mutant Drosophila larve
Comparison of transcript profiling in Gcn5 and Ada2a drosophila mutant larve, with previously published transcript profiling in Nurf301 mutants (Badenhorst, P. et al. Genes Dev 19, 2540-5, 2005).
ORGANISM(S): Drosophila melanogaster 
2007-12-07 | E-MEXP-1208 | biostudies-arrayexpress
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