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TranscriptomicsEffects of KAT2B and WDR5 depletion on hepatocyte gene expression
During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormon...
ORGANISM(S): Mus musculus 
2014-04-21 | E-GEOD-47179 | biostudies-arrayexpress
TranscriptomicsAlteration of gene expression in differentiating C2C12 cells upon inhibition of PCAF by embelin
KAT2B (PCAF) belongs to GNAT family of lysine acetyltransferases (KAT), which specifically acetylates histone H3K9 residue and several nonhistone proteins. PCAF is also a transcription coactivator. Due to the lack of PCAF, KAT specific small molecule inhibitor, the exclusive role of the acetyltransf...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-39827 | biostudies-arrayexpress
ProteomicsDependency of NELF-E-KAT2B epigenetic axis in breast cancer carcinogenesis
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Here, we identified the transcriptional complex, NELF (Negative elongation factor), as an important regulator of this process. Using cancer cell lines and patient-derived tumor organoids, we demonstrated th...
ORGANISM(S): Homo Sapiens (human) 
2023-01-28 | PXD031304 | JPOST Repository
TranscriptomicsAlteration of gene expression in HEK 293T cells upon inhibition of PCAF by embelin
KAT2B (PCAF) belongs to GNAT family of lysine acetyltransferases (KAT), which specifically acetylates histone H3K9 residue and several nonhistone proteins. PCAF is also a transcription coactivator. Due to the lack of PCAF, KAT specific small molecule inhibitor, the exclusive role of the acetyltransf...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-39828 | biostudies-arrayexpress
ProteomicsHuman KAT2A/B-acetylome MudPIT
Comprehensive identification of acetylated proteins targeted by the lysine acetyltransferases KAT2A (GCN5) and KAT2B (PCAF), in human cells. KAT2A/B-dependent acetylated proteins were identified by comparing acetylated proteins in whole cell extract of control cells and cells in which KAT2A and KAT2...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD004669 | Pride
Acetylation Non-histone targets Kat2a(gcn5) Centrosome duplication Kat2b (pcaf) Plk4 
TranscriptomicsAlteration of gene expression in differentiating C2C12 cells upon inhibition of PCAF by embelin
KAT2B (PCAF) belongs to GNAT family of lysine acetyltransferases (KAT), which specifically acetylates histone H3K9 residue and several nonhistone proteins. PCAF is also a transcription coactivator. Due to the lack of PCAF, KAT specific small molecule inhibitor, the exclusive role of the acetyltransf...
ORGANISM(S): Mus musculus 
2013-03-31 | GSE39827 | GEO
TranscriptomicsAlteration of gene expression in HEK 293T cells upon inhibition of PCAF by embelin
KAT2B (PCAF) belongs to GNAT family of lysine acetyltransferases (KAT), which specifically acetylates histone H3K9 residue and several nonhistone proteins. PCAF is also a transcription coactivator. Due to the lack of PCAF, KAT specific small molecule inhibitor, the exclusive role of the acetyltransf...
ORGANISM(S): Homo sapiens 
2013-03-31 | GSE39828 | GEO
ProteomicsPALB2 acetylation by KAT2A/B (GCN5/PCAF) in vitro
PArtner and Localizer of BRCA2 (PALB2) is essential to maintain genome stability in human cells. Upon DNA damage by double DNA strand breaks, PALB2 is required to repair DNA by homologous recombination. In undamaged conditions, PALB2 protects coding regions, by preventing DNA stress due to collision...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD014681 | Pride
Acetylation Dna repair 
TranscriptomicsEffects of KAT2B and WDR5 depletion on hepatocyte gene expression
During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormon...
ORGANISM(S): Mus musculus 
2014-04-21 | GSE47179 | GEO
UnknownGcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.
Not available
S-EPMC4253493 | biostudies-literature
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