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MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
TranscriptomicsA novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus
IL-5 is a key cytokine that plays an important role in the development of pathological conditions in chronic allergic inflammation. Identification of a strategy to inhibit IL-5 production is important for establishment of new therapies for allergic inflammation. We found that SH-2251, a novel thio...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-42131 | biostudies-arrayexpress
TranscriptomicsFetal malformations and early embryonic gene expression response in Cynomolgus monkeys maternally exposed to thalidomide
EXPERIMENT: The animal experiments were performed at Shin Nippon Biomedical Laboratories (SNBL), Ltd. (Kagoshima, Japan) in compliance with the Guideline for Animal Experimentation (1987), and in accordance with the Law Concerning the Protection and Control of Animals (1973) and the Standards Relati...
ORGANISM(S): Macaca fascicularis 
2010-06-20 | E-GEOD-15542 | biostudies-arrayexpress
ProteomicsMulti-omics Characterization of Neutrophil Extracellular Trap Formation in Severe and Mild COVID-19 Infections
Analysis of human plasma from patients either infected or not infected with COVID-19
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-28 | MSV000089330 | MassIVE
ProteomicsProteomic analyses of iron deprived NK92 cells with deferoxamine or PPMX-T003
This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody)...
ORGANISM(S): Homo Sapiens (human) 
2025-07-04 | PXD059223 | JPOST Repository
UnknownCryo-EM structure of immunodominant protein P1 from human pathogen Mycoplasma pneumoniae on graphene oxide grid
Not available
EMPIAR-10518 | biostudies-other
ProteomicsGrafting induced pluripotent stem cells-derived tenocytes contribute to recovery of motor function after Achilles tendon rupture in rat
Self-renewal of tendons is rare since the vascular formation inside is extremely poor, thus reconstructive surgery using autologous tendons has been often taken place in the case of severe injury. However, the rate of re-injury after surgery is relatively high, and collection of autologous tendons l...
ORGANISM(S): Homo Sapiens (human) 
2021-07-01 | PXD020887 | JPOST Repository
ProteomicsMS data on PAF15 binding proteins
GST pull-down mass spectrometry data on PAF15 binding proteins
ORGANISM(S): Cellular Organisms 
2023-02-24 | PXD034088 | JPOST Repository
ProteomicsNRDC-IP
IP-MS analysis against endogenous NRDC using megakaryocyte cell lysates.
ORGANISM(S): Homo Sapiens (human) 
2018-07-19 | PXD009739 | JPOST Repository
UnknownMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Not available
S-EPMC5968830 | biostudies-literature
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