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ProteomicsMass spec analysis of primary human erythroid cultures (healthy or thalassemic and treated or untreated with Decitabine)
Reactivation of gamma-globin is considered a promising approach for the treatment of beta-thalassaemia and sickle cell disease. Therapeutic induction of gamma-globin expression is fraught with lack of suitable therapeutic targets. In order to identify new potential targets we analysed the changes in...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD006889 | Pride
Human Decitabine Hbf Lc-ms Primary erythroid cultures 
TranscriptomicsIntestinal epithelial HuR balances counteracting RNA networks to protect against intestinal inflammation and cancer. PART 2 Differentiality in mRNA expression between Control mice and mice overexpressing Elavl1.
Elavl1/HuR is a ubiquitous and conserved RNA-binding protein that binds to a U-rich RNA motif that shuttles between nucleus and cytoplasm. In epithelia, the elevated expression of HuR assumingly promotes degeneration and cancer suggesting that its generic suppression may provide clinical benefits. I...
ORGANISM(S): Mus musculus 
2020-07-01 | E-MTAB-4017 | biostudies-arrayexpress
TranscriptomicsIntestinal epithelial HuR balances counteracting RNA networks to protect against intestinal inflammation and cancer. PART 3 RIP chip by array
Elavl1/HuR is a ubiquitous and conserved RNA-binding protein that binds to a U-rich RNA motif that shuttles between nucleus and cytoplasm. In epithelia, the elevated expression of HuR assumingly promotes degeneration and cancer suggesting that its generic suppression may provide clinical benefits. I...
ORGANISM(S): Mus musculus 
2018-01-01 | E-MTAB-4018 | biostudies-arrayexpress
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