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TranscriptomicsMethylation profiling of pediatric acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is categorized as the M3 subtype in the French-American-British classification system. It represents a unique subtype of acute myeloid leukemia (AML) characterized by the t(15;17)/PML::RARA fusion, with leukemic cells arrested at the promyelocytic stage of myelopoi...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-15728 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pediatric acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is categorized as the M3 subtype in the French-American-British classification system. It represents a unique subtype of acute myeloid leukemia (AML) characterized by the t(15;17)/PML::RARA fusion, with leukemic cells arrested at the promyelocytic stage of myelopoi...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-15773 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse rectum after physiological stress
Using isolation stress model, we showed that goblet cell-dependent mucosal barrier functions in the mouse rectum was more vulnerable to stress than the colon. We also found that isolation stress specifically stimulated IL-18 production only in the rectum. Furthermore, the crucial role of IL-18 in th...
ORGANISM(S): Mus musculus 
2009-02-26 | E-GEOD-11910 | biostudies-arrayexpress
TranscriptomicsTIAR represses c-Myc biosynthesis following ultraviolet light irradiation
RNA was isolated from material that had been subjected to immunoprecipitation (IP) from RKO cells that were either left untreated or irradiated with 20 J/m2 UVC and collected 1h later; IP assays were carried out using either an antibody recognizing RNA-binding protein TIAR, or using a control IgG1 a...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1433 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HCT116 clones stably expressing vegf 5 prime UTR reveals a novel tumor promoting function
VEGF165 is one of the key regulators of tumor development. Using HCT116 cells transfected with full-length vegf mRNA, full-length vegf mRNA with mutations of H9D and L14E, mutated vegf mRNAs lacking untranslated regions (UTRs), and 5â??UTR mutated between nt 591 and nt 746, we found that vegf 5â??UT...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8888 | biostudies-arrayexpress
TranscriptomicsConcurrent Versus Individual Binding of HuR and AUF1 to Common Labile Target mRNAs
RNA was isolated from material that had been immunoprecipitated (IP) from Hela cells using antibodies recognizing RNA-binding proteins HuR or AUF1, as well as using a control IgG1 antibody. RNA was reverse-transcribed in the presence of [alpha-33P]dCTP and the radiolabeled product used to hybridize ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1361 | biostudies-arrayexpress
UnknownHyaluronan Production by Renomedullary Interstitial Cells: Influence of Endothelin, Angiotensin II and Vasopressin.
Not available
S-EPMC5751302 | biostudies-literature
TranscriptomicsTIAR represses c-Myc biosynthesis following ultraviolet light irradiation-2
Untreated or 20 J/m2 UVC treated RKO cells were collected and RNA from either whole-cell lysates or from polysomal fractions was extracted at 0 (untreated), 3, 6, and 12 h after treatment. RNA from whole-cell lysates or each of 11 polysomal fraction was reverse-transcribed in the presence of [α-33...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1440 | biostudies-arrayexpress
TranscriptomicsAutism-associated gene expression signatures in peripheral blood leucocytes
Using DNA microarray as a global approach to understanding the molecular basis of autism, we examined gene expression profiling in peripheral blood from 21 young adults with autism spectrum disorder (ASD) and healthy mothers having children with ASD, between whom there was no blood relationship. Sev...
ORGANISM(S): Homo sapiens 
2011-01-13 | E-GEOD-26415 | biostudies-arrayexpress
TranscriptomicsDeficient of IL-18 in mice leads to the reduction of neuropeptides in the amygdala related with behavioral change
Interleukin (IL)-18 is recognized as a multifunctional mediator in inflammation and immune responses. In addition, the production of IL-18 is stimulated by physiological and/or psychological stress implicated in several behavioral disorders. However, it still remains unclear about the role of IL-18 ...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-19522 | biostudies-arrayexpress
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