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TranscriptomicsTranscriptomics of the traditional Japanese medicine juzentaihoto (JTX) on small intestines on germfree mice
Juzehtaihoto, a Japanese traditional medicine has been used for the treatment of various kinds of disease or disorders in an enteric-flora dependent manner. Here, we performed transcriptome analysis using Affymetrix GeneChip on small intestine (SI) of germ-free (GF) and specific pathogen free (SPF)...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-32084 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of the traditional Japanese medicine juzentaihoto (JTX) on large intestines on germfree mice
Juzehtaihoto, a Japanese traditional medicine has been used for the treatment of various kinds of diseases or disorders in an enteric-flora dependent manner. Here, we performed transcriptome analysis using Affymetrix GeneChip on large intestine (LI) of germ-free (GF) and specific pathogen free (SPF...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-32083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse large intestine from animals with and without enteric flora
Although microbiota plays a critical role for the normal development and function of host immune systems, the detail of the influence, especially on those in the large intestine (LI), remains unknown. Here, we performed transcriptome analysis using Affymetrix GeneChip on LI of germ-free (GF) and sp...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8006 | biostudies-arrayexpress
TranscriptomicsTwist1 Directly Regulates Genes That Promote Cell Proliferation and Migration in Developing Heart Valves
Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells. In the developing heart, Twist1 is highly expressed in endocardial cushion (ECC) valve mesenchymal cells and is down regulated during valve d...
ORGANISM(S): Mus musculus 
2011-07-27 | E-GEOD-30953 | biostudies-arrayexpress
TranscriptomicsChronic Intermittent Hypoxia Increases Alveolar Surface Area in Adult Mice
Obstructive sleep apnea (OSA) leads to increased cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O2 profile in patients with OSA. We ex...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21409 | biostudies-arrayexpress
TranscriptomicsGene expression in aerial hyphae in response to rep1 deletion in Ustilago maydis
The rep1 gene of the maize pathogen Ustilago maydis encodes a pre-pro-protein that is processed in the secretory pathway into 11 peptides. These so-called repellents form amphipathic amyloid fibrils at the surface of aerial hyphae. Strains in which the rep1 gene is inactivated (M-bM-^HM-^Frep1 strai...
ORGANISM(S): Ustilago maydis 
2011-05-01 | E-GEOD-21490 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after induction of WTX in HEK293 cells
WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in beta-catenin turnover, but its effect on nuclear proteins is unknown. We report an interaction between WTX and p53, derived from the unexpected observ...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-34715 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Caenorhabditis elegans treated with Dichlorvos and fenamiphos, to investigate it as a genomic model for toxicology
Effective toxicological testing of the vast number of new and existing chemicals currently in use will require efficient and cost effective methods. We evaluated the utility of a simple, low cost toxicity testing system employing the nematode Caenorhabditis elegans to identify toxicologically releva...
ORGANISM(S): Caenorhabditis elegans 
2009-06-24 | E-GEOD-12298 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of YY2 versus YY1 target genes
Yin Yang 1 (YY1) is a critical transcription factor controlling cell proliferation, development and DNA damage responses. Although two homologous Drosophila YY family members (pleiohomeotic (pho)) and pleiohomeotic-like (phol)) are redundant, the functional significance of a recently described mamma...
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-14964 | biostudies-arrayexpress
TranscriptomicsCharacterization of the autoaggregation response of Fusobacterium nucleatum
Fusobacterium nucleatum is a Gram negative oral bacterial species associated with periodontal disease progression. This species is perhaps best known for its ability to adhere to a vast array of other bacteria and eukaryotic cells. Numerous studies of F. nucleatum have examined various coaggregation...
ORGANISM(S): Fusobacterium nucleatum 
2009-10-15 | E-GEOD-18554 | biostudies-arrayexpress
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