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TranscriptomicsFumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats
Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate (DMF), exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid este...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-MTAB-2406 | biostudies-arrayexpress
TranscriptomicsDownregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, a quantitative trait locus (QTL) influencing blood pressure, left ventricular mass and heart...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat 3 months old male Wistar animals by aorto-caval fistula reveals alterations in systemic substrate metabolism in rat volume-overload model of chronic heart failure
Abnormalities in metabolism of energetic substrates may play a role in progression of chronic heart failure (HF). The goal of the study was to examine the extent and mechanisms of metabolic alterations in rat model of chronic HF due to volume overload. Volume overload was induced in 3 months old mal...
ORGANISM(S): Rattus norvegicus 
2011-10-05 | E-MTAB-190 | biostudies-arrayexpress
TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsSalsalate ameliorates metabolic disturbances by reducing inflammation and oxidative stress and by activating brown adipose tissue in spontaneously hypertensive rats
Metabolic syndrome is associated with chronic low-grade inflammation which plays an important role in the pathogenesis of insulin resistance. Salsalate is a non-steroidal anti-inflammatory drug that reduces levels of inflammatory mediators. In the current study, we tested the effects of salsalate on...
ORGANISM(S): Rattus norvegicus 
2017-01-15 | E-MTAB-5079 | biostudies-arrayexpress
TranscriptomicsCD36-DEFICIENT CONGENIC STRAINS SHOW IMPROVED GLUCOSE TOLERANCE AND DISTINCT SHIFTS IN METABOLIC AND TRANSCRIPTOMIC PROFILES
Deficiency of fatty acid translocase Cd36 has been shown to play major role in pathogenesis of metabolic syndrome components in the spontaneously hypertensive rat (SHR). We have tested the hypothesis that effects of Cd36 mutation on features of metabolic syndrome are contextually-dependent on genomi...
ORGANISM(S): Rattus norvegicus 
2012-02-01 | E-GEOD-33597 | biostudies-arrayexpress
TranscriptomicsAutocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue by affecting expression of genes involved in skeletal muscle and connective tissue development, inflammation, MAPK, insulin and calcium signaling.
Resistin has been originally identified as an adipokine that links obesity to insulin resistance in mice. In our previous studies in spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin (Retn) transgene specifically in adipose tissue (SHR-Retn), we observed an increa...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3787 | biostudies-arrayexpress
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